A new boronate ester-based crosslinking strategy allows the design of nonswelling and long-term stable dynamic covalent hydrogels.

Autor: Lagneau N; Nantes Université, Oniris, CHU Nantes, INSERM, Regenerative Medicine and Skeleton, RMeS, UMR 1229, F-44000 Nantes, France. vianney.delplace@univ-nantes.fr., Terriac L; Nantes Université, Oniris, CHU Nantes, INSERM, Regenerative Medicine and Skeleton, RMeS, UMR 1229, F-44000 Nantes, France. vianney.delplace@univ-nantes.fr., Tournier P; Nantes Université, Oniris, CHU Nantes, INSERM, Regenerative Medicine and Skeleton, RMeS, UMR 1229, F-44000 Nantes, France. vianney.delplace@univ-nantes.fr., Helesbeux JJ; Substances d'Origine Naturelle et Analogues Structuraux, SFR4207 QUASAV, Université d'Angers, Angers, France., Viault G; Substances d'Origine Naturelle et Analogues Structuraux, SFR4207 QUASAV, Université d'Angers, Angers, France., Séraphin D; Substances d'Origine Naturelle et Analogues Structuraux, SFR4207 QUASAV, Université d'Angers, Angers, France., Halgand B; Nantes Université, Oniris, CHU Nantes, INSERM, Regenerative Medicine and Skeleton, RMeS, UMR 1229, F-44000 Nantes, France. vianney.delplace@univ-nantes.fr., Loll F; Nantes Université, Oniris, CHU Nantes, INSERM, Regenerative Medicine and Skeleton, RMeS, UMR 1229, F-44000 Nantes, France. vianney.delplace@univ-nantes.fr., Garnier C; INRAE, UR1268 Biopolymères Interactions Assemblages, F-44300 Nantes, France., Jonchère C; INRAE, UR1268 Biopolymères Interactions Assemblages, F-44300 Nantes, France., Rivière M; Nantes Université, CNRS, CEISAM, UMR 6230, F-44000 Nantes, France., Tessier A; Nantes Université, CNRS, CEISAM, UMR 6230, F-44000 Nantes, France., Lebreton J; Nantes Université, CNRS, CEISAM, UMR 6230, F-44000 Nantes, France., Maugars Y; Nantes Université, Oniris, CHU Nantes, INSERM, Regenerative Medicine and Skeleton, RMeS, UMR 1229, F-44000 Nantes, France. vianney.delplace@univ-nantes.fr., Guicheux J; Nantes Université, Oniris, CHU Nantes, INSERM, Regenerative Medicine and Skeleton, RMeS, UMR 1229, F-44000 Nantes, France. vianney.delplace@univ-nantes.fr., Le Visage C; Nantes Université, Oniris, CHU Nantes, INSERM, Regenerative Medicine and Skeleton, RMeS, UMR 1229, F-44000 Nantes, France. vianney.delplace@univ-nantes.fr., Delplace V; Nantes Université, Oniris, CHU Nantes, INSERM, Regenerative Medicine and Skeleton, RMeS, UMR 1229, F-44000 Nantes, France. vianney.delplace@univ-nantes.fr.
Jazyk: angličtina
Zdroj: Biomaterials science [Biomater Sci] 2023 Mar 14; Vol. 11 (6), pp. 2033-2045. Date of Electronic Publication: 2023 Mar 14.
DOI: 10.1039/d2bm01690g
Abstrakt: Dynamic hydrogels are viscoelastic materials that can be designed to be self-healing, malleable, and injectable, making them particularly interesting for a variety of biomedical applications. To design dynamic hydrogels, dynamic covalent crosslinking reactions are attracting increasing attention. However, dynamic covalent hydrogels tend to swell, and often lack stability. Boronate ester-based hydrogels, which result from the dynamic covalent reaction between a phenylboronic acid (PBA) derivative and a diol, are based on stable precursors, and can therefore address these limitations. Yet, boronate ester formation hardly occurs at physiological pH. To produce dynamic covalent hydrogels at physiological pH, we performed a molecular screening of PBA derivatives in association with a variety of diols, using hyaluronic acid as a polymer of interest. The combination of Wulff-type PBA (wPBA) and glucamine stood out as a unique couple to obtain the desired hydrogels. We showed that optimized wPBA/glucamine hydrogels are minimally- to non-swelling, stable long term (over months), tunable in terms of mechanical properties, and cytocompatible. We further characterized their viscoelastic and self-healing properties, highlighting their potential for biomedical applications.
Databáze: MEDLINE
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