| Autor: |
Abrahao A; Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.; Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada., Phung L; Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada., Fam D; St. Joseph's Health Centre Toronto, United Health, Toronto, Ontario, Canada., Escorcio-Bezerra ML; Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil., Robinson LR; Division of Physical Medicine and Rehabilitation, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada., Jones KE; Faculty of Kinesiology, Sport and Recreation, University of Alberta, Edmonton, Alberta, Canada., Zinman L; Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.; Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada. |
| Abstrakt: |
Motor unit number index of the upper trapezius (MUNIX-Trapezius) is a candidate biomarker for bulbar lower motor neuron function; however, reliability data is incomplete. To assess MUNIX-Trapezius reliability in controls, we conducted a systematic review, a cross-sectional study ( n = 20), and a meta-analysis. We demonstrated a high inter- and intra-rater intraclass correlation (0.86 and 0.94, respectively), indicating that MUNIX-Trapezius is reliable with between-study variability moderated by age and MUNIX technique. With further validation, this measure can serve as a disease monitoring and response biomarker of bulbar function in the therapeutic development for amyotrophic lateral sclerosis. |
