Cardiovascular diseases worsen the maternal prognosis of COVID-19.

Autor:	Testa CB; Disciplina de Obstetrícia, Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil., Godoi LG; DaSLab (Data Science Lab), Department of Statistics, Federal University of Espírito Santo, Vitória/ES, Brazil., Bortolotto MRFL; Divisão de Clínica Obstétrica, Instituto Central do Hospital das Clínicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil., Monroy NAJ; DaSLab (Data Science Lab), Department of Statistics, Federal University of Espírito Santo, Vitória/ES, Brazil., Mattos BR; DaSLab (Data Science Lab), Department of Statistics, Federal University of Espírito Santo, Vitória/ES, Brazil., Rodrigues AS; DaSLab (Data Science Lab), Department of Statistics, Federal University of Espírito Santo, Vitória/ES, Brazil., Francisco RPV; Disciplina de Obstetrícia, Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	PloS one [PLoS One] 2023 Feb 07; Vol. 18 (2), pp. e0266792. Date of Electronic Publication: 2023 Feb 07 (Print Publication: 2023).
DOI:	10.1371/journal.pone.0266792
Abstrakt:	Cardiovascular diseases (CVD) are a risk factor for severe cases of COVID-19. There are no studies evaluating whether the presence of CVD in pregnant and postpartum women with COVID-19 is associated with a worse prognosis. In an anonymized open database of the Ministry of Health, we selected cases of pregnant and postpartum women who were hospitalized due to COVID-19 infection and with data regarding their CVD status. In the SIVEP GRIPE data dictionary, CVD is defined as "presence of cardiovascular disease", excluding those of neurological and nephrological causes that are pointed out in another field. The patients were divided into two groups according to the presence or absence of CVD (CVD and non-CVD groups). Among the 1,876,953 reported cases, 3,562 confirmed cases of pregnant and postpartum women were included, of which 602 had CVD. Patients with CVD had an older age (p<0,001), a higher incidence of diabetes (p<0,001) and obesity (p<0,001), a higher frequency of systemic (p<0,001) and respiratory symptoms (p<0,001). CVD was a risk factor for ICU admission (p<0,001), ventilatory support (p = 0.004) and orotracheal intubation in the third trimester (OR 1.30 CI95%1.04-1.62). The group CVD had a higher mortality (18.9% vs. 13.5%, p<0,001), with a 32% higher risk of death (OR 1.32 CI95%1.16-1.50). Moreover, the risk was increased in the second (OR 1.94 CI95%1.43-2.63) and third (OR 1.29 CI95%1.04-1.60) trimesters, as well as puerperium (OR 1.27 CI95%1.03-1.56). Hospitalized obstetric patients with CVD and COVID-19 are more symptomatic. Their management demand more ICU admission and ventilatory support and the mortality is higher. Competing Interests: The authors have declared that no competing interests exist. (Copyright: © 2023 Testa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze:	MEDLINE
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