Image-based response assessment during immunotherapy in skin cancer.

Autor: Mayer KE; Clinic and Polyclinic for Dermatology and Allergology, Technical University Munich, Munich, Germany., Gaa J; Institute for Diagnostic and Interventional Radiology, Technical University Munich, Munich, Germany., Biedermann T; Clinic and Polyclinic for Dermatology and Allergology, Technical University Munich, Munich, Germany., Posch C; Clinic and Polyclinic for Dermatology and Allergology, Technical University Munich, Munich, Germany.; Faculty of Medicine, Sigmund Freud University Vienna, Austria.
Jazyk: angličtina
Zdroj: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG [J Dtsch Dermatol Ges] 2023 Feb; Vol. 21 (2), pp. 107-114. Date of Electronic Publication: 2023 Feb 07.
DOI: 10.1111/ddg.14941
Abstrakt: Immune-checkpoint inhibitors and further immunotherapeutic treatment strategies have significantly extended therapy options for melanoma and other skin cancer entities over the last decade. In the context of a broader application of immunotherapeutic approaches, sufficient ways to monitor the course of the disease during therapy are required. Immunotherapies are based on different ways of modulating the immune system. This leads to complex clinical response patterns including pseudoprogression and others, requiring an adaptation of conventional diagnostic imaging tools or the introduction of novel technologies. In this review, current non-invasive imaging approaches for response assessment during immunotherapies in skin cancers as well as their limitations are discussed. To overcome present hurdles, promising alternatives to better address novel imaging features during immunotherapy are depicted giving an outlook on what can be expected in the future.
(© 2023 The Authors. Journal der Deutschen Dermatologischen Gesellschaft published by John Wiley & Sons Ltd on behalf of Deutsche Dermatologische Gesellschaft.)
Databáze: MEDLINE
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