Hantavirus infection as a risk factor for chronic kidney disease of unknown aetiology (CKDu) and its prevalence in endemic areas of Sri Lanka since 2010 according to a retrospective serological analysis.

Autor: Gamage CD; Department of Microbiology, Faculty of Medicine, University of Peradeniya, 20400 Peradeniya, Sri Lanka., Nanayakkara S; School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Surry Hills, NSW 2010, Australia.; Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan., Sarathkumara YD; Department of Microbiology, Faculty of Medicine, University of Peradeniya, 20400 Peradeniya, Sri Lanka.; Australian Institute of Tropical Health and Medicine, James Cook University, Smithfield, QLD 4870, Australia., Muthusinghe DS; Graduate School of Infectious Diseases, Hokkaido University, Sapporo 060-0815, Japan.; Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan., Shimizu K; Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo 060-8638, Japan., Arikawa J; Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo 060-8638, Japan., Lokupathirage SMW; Graduate School of Infectious Diseases, Hokkaido University, Sapporo 060-0815, Japan.; Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan., Nanayakkara N; Nephrology and Transplantation Unit, Teaching Hospital Kandy, 20000 Kandy, Sri Lanka., Gunarathne L; Renal Clinic, District Hospital, 90750 Girandurukotte, Sri Lanka., Chandrajith R; Department of Geology, Faculty of Science, University of Peradeniya, 20400 Peradeniya, Sri Lanka., Harada KH; Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan., Koizumi A; Institute of Public Health and Welfare Research, Ukyo-ku, Kyoto 616-8141, Japan.; Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan., Yoshimatsu K; Graduate School of Infectious Diseases, Hokkaido University, Sapporo 060-0815, Japan.; Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan.
Jazyk: angličtina
Zdroj: Journal of medical microbiology [J Med Microbiol] 2022 Dec; Vol. 71 (12).
DOI: 10.1099/jmm.0.001630
Abstrakt: Background. Chronic kidney disease of unknown aetiology (CKDu) is a major public health problem in Sri Lanka, especially among agrarian communities. Although the cause of CKDu is still unknown, hantavirus infection has been proposed as a risk factor. Methods. This study was performed using serological samples collected from two CKDu-endemic areas, Anuradhapura (2010) and Badulla districts (2010 and 2016), and a non-endemic area, Matale (2016) district. The presence of anti-Thailand orthohantavirus IgG antibodies was investigated in serum samples. Hantavirus seroprevalence and demographic data were epidemiologically analysed. Results. Seroprevalence was higher in CKDu patients (40.6-60.0 %) and healthy individuals in CKDu-endemic areas (17.6-25.5 %) than in healthy individuals in non-endemic areas (3.0 %). Statistically significant odds ratios (ORs) for hantavirus infection in CKDu patients were detected in CKDu-endemic areas [ORs: 3.2 and 3.1; 95 % confidence interval (CI): 1.8-5.5 and 1.8-5.2 in Anuradhapura and Badulla districts in 2010; and OR: 4.4, 95 % CI: 2.3-8.5 in 2016 in Badulla district). Furthermore, the OR for hantavirus infection in Badulla district has increased in the last decade from 3.1 (95 % CI: 1.8-5.3) to 4.4 (95 % CI: 2.3-8.5). Conclusion. Hantavirus infection has been prevalent in two distant CKDu-endemic areas since 2010. The observed significant association of hantavirus seropositivity with CKDu indicates a possible role of hantavirus infection in CKDu pathogenesis.
Databáze: MEDLINE