Identification of Immune-Related Candidate Biomarkers in Plasma of Patients with Sporadic Vestibular Schwannoma: Candidate Plasma Biomarkers in Vestibular Schwannoma.

Autor:	Vasilijic S; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, US.; Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, US., Atai NA; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, US., Hyakusoku H; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, US.; Department of Otorhinolaryngology, Yokosuka Kyosai Hospital, Kanagawa, Japan., Worthington S; Harvard Institute for Quantitative Social Science, Harvard University, Cambridge, MA, US., Ren Y; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, US., Sagers JE; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, US., Sahin MI; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, US., Fujita T; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, US., Landegger LD; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, US., Lewis R; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, US.; Department of Neurology, Harvard Medical School, Boston, MA, US., Welling DB; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, US., Stankovic KM; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, US.; Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, US.; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, US.; Wu Tsai Neuroscience Institute, Stanford University, Stanford, CA, US.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 26. Date of Electronic Publication: 2023 Jan 26.
DOI:	10.1101/2023.01.24.525436
Abstrakt:	Vestibular schwannoma (VS) is intracranial tumor arising from neoplastic Schwann cells, causing hearing loss in about 95% of patients. The traditional belief that hearing deficit is caused by physical expansion of the VS, compressing the auditory nerve, does not explain the common clinical finding that patients with small tumors can have profound hearing loss, suggesting that tumor-secreted factors could influence hearing ability in VS patients. Here, we conducted profiling of patients' plasma for 67 immune-related factors on a large cohort of VS patients (N>120) and identified candidate biomarkers associated with tumor growth (IL-16 and S100B) and hearing (MDC). We identified the 7-biomarker panel composed of MCP-3, BLC, S100B, FGF-2, MMP-14, eotaxin, and TWEAK that showed outstanding discriminatory ability for VS. These findings revealed possible therapeutic targets for VS-induced hearing loss and provided a unique diagnostic tool that may predict hearing change and tumor growth in VS patients and may help inform the ideal timing of tumor resection to preserve hearing. Competing Interests: Competing interests: Authors declare that they have no competing interests.
Databáze:	MEDLINE
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