Dual Trajectories of Antiretroviral Therapy Adherence and Polypharmacy in Women with HIV in the United States.

Autor: Elbur AI; Massachusetts General Hospital, Harvard Medical School., Ghebremichael M; The Ragon Institute of MGH, MIT, and Harvard., Konkle-Parker D; University of Mississippi Medical Center., Jones DL; University of Miami Miller School of Medicine., Collins S; Emory University School of Medicine., Adimora AA; University of North Carolina at Chapel Hill., Schneider MF; Johns Hopkins Bloomberg School of Public Health., Cohen MH; Stroger Hospital of Cook County., Tamraz B; University of California, San Francisco., Plankey M; Georgetown University Medical Center., Wilson T; SUNY Downstate Health Sciences University., Adedimeji A; Albert Einstein College of Medicine., Haberer JE; Massachusetts General Hospital, Harvard Medical School., Jacobson DL; Harvard T. H. Chan School of Public Health.
Jazyk: angličtina
Zdroj: Research square [Res Sq] 2023 Jan 23. Date of Electronic Publication: 2023 Jan 23.
DOI: 10.21203/rs.3.rs-2443973/v1
Abstrakt: Background Polypharmacy, using five or more medications, may increase the risk of nonadherence to prescribed treatment. We aimed to identify the interrelationship between trajectories of adherence to antiretroviral therapy (ART) and polypharmacy. Methods We included women with HIV (aged ≥ 18) enrolled in the Women's Interagency HIV Study in the United States from 2014 to 2019. We used group-based trajectory modeling (GBTM) to identify trajectories of adherence to ART and polypharmacy and the dual GBTM to identify the interrelationship between adherence and polypharmacy. Results Overall, 1,538 were eligible (median age of 49 years). GBTM analysis revealed five latent trajectories of adherence with 42% of women grouped in the consistently moderate trajectory. GBTM identified four polypharmacy trajectories with 45% categorized in the consistently low group. Conclusions The joint model did not reveal any interrelationship between ART adherence and polypharmacy trajectories. Future research should consider examining the interrelationship between both variables using objective measures of adherence.
Databáze: MEDLINE
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