Effects of Euterpe oleracea Mart. extract on Candida spp. biofilms.

Autor: Brito LL; Postgraduate Program in Adult Health, Federal University of Maranhão, Av. Dos Portugueses, 1966, Bacanga, São Luís, MA, 65080-805, Brazil., Borges KRA; Postgraduate Program in Adult Health, Federal University of Maranhão, Av. Dos Portugueses, 1966, Bacanga, São Luís, MA, 65080-805, Brazil., Silva GX; Nucleum of Basic and Applied Immunology, Federal University of Maranhão, São Luís, Maranhão, Brazil., da Silva MACN; Postgraduate Program in Internal Medicine, University of Campinas, Campinas, São Paulo, Brazil.; Federal University of Maranhão, Imperatriz, Maranhão, Brazil., de Nazaré Silva Alves R; Postgraduate Program in Adult Health, Federal University of Maranhão, Av. Dos Portugueses, 1966, Bacanga, São Luís, MA, 65080-805, Brazil., Teles AM; Nucleum of Basic and Applied Immunology, Federal University of Maranhão, São Luís, Maranhão, Brazil., do Carmo Lacerda Barbosa M; Nucleum of Basic and Applied Immunology, Federal University of Maranhão, São Luís, Maranhão, Brazil., Muniz Filho WE; Nucleum of Basic and Applied Immunology, Federal University of Maranhão, São Luís, Maranhão, Brazil., de Barros Bezerra GF; Postgraduate Program in Adult Health, Federal University of Maranhão, Av. Dos Portugueses, 1966, Bacanga, São Luís, MA, 65080-805, Brazil.; Nucleum of Basic and Applied Immunology, Federal University of Maranhão, São Luís, Maranhão, Brazil., do Desterro Soares Brandão Nascimento M; Postgraduate Program in Adult Health, Federal University of Maranhão, Av. Dos Portugueses, 1966, Bacanga, São Luís, MA, 65080-805, Brazil. m.desterro.soares@gmail.com.; Nucleum of Basic and Applied Immunology, Federal University of Maranhão, São Luís, Maranhão, Brazil. m.desterro.soares@gmail.com.
Jazyk: angličtina
Zdroj: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] [Braz J Microbiol] 2023 Mar; Vol. 54 (1), pp. 29-36. Date of Electronic Publication: 2023 Feb 07.
DOI: 10.1007/s42770-023-00919-1
Abstrakt: Problem of Research: Candida spp. biofilms are complex microbial communities that have been associated with increasing resistance to clinically available antifungal drugs. Hence, novel pharmacological approaches with ability to inhibit biofilm formation have been investigated.
Aim of Study: The aim was to analyze in vitro antifungal activity of Euterpe oleracea Mart. (açaí berry) extract on biofilm strains of Candida albicans, C. parapsilosis, and C. tropicalis that were formed on abiotic surfaces.
Remarkable Methodology: Biofilms of C. albicans, C. parapsilosis, and C. tropicalis were grown in vitro. They were then treated with E. oleracea Mart. extract at different concentrations (7.8, 15.6, 31.2, 62.5, 125, 250, 500, and 1000 μg/mL) for evaluation of both biofilm removal and anti-biofilm activity.
Remarkable Results: All Candida species analyzed formed biofilms on abiotic surfaces. Yet, increased biofilm formation was displayed for C. tropicalis in comparison with the other two species. E. oleracea Mart. extract was shown to inhibit biofilm formation at all concentrations used when compared to no treatment (p < 0.05).
Significance of the Study: In the current study, the extract of E. oleracea Mart. demonstrated antifungal activity against Candida albicans, C. parapsilosis, and C. tropicalis biofilms, regardless of the dose utilized. These results are important to evaluate a natural product as antifungal for Candida species.
(© 2023. The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.)
Databáze: MEDLINE
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