Eumitrins I-K: three new xanthone dimers from the lichen Usnea baileyi.

Autor: Nguyen VK; Institute of Fundamental and Applied Sciences, Duy Tan University, Ho Chi Minh City, Vietnam. nguyenvankieu2@duytan.edu.vn.; Faculty of Natural Sciences, Duy Tan University, Da Nang, Vietnam. nguyenvankieu2@duytan.edu.vn., Dong PS; Institute of Fundamental and Applied Sciences, Duy Tan University, Ho Chi Minh City, Vietnam.; Faculty of Natural Sciences, Duy Tan University, Da Nang, Vietnam., Nguyen-Si HV; Institute of Fundamental and Applied Sciences, Duy Tan University, Ho Chi Minh City, Vietnam.; Faculty of Natural Sciences, Duy Tan University, Da Nang, Vietnam., Sangvichien E; Lichen Research Unit and Lichen Herbarium, Department of Biology, Faculty of Science, Ramkhamhaeng University, Bangkapi, Bangkok, 10240, Thailand., Tran TN; Department of Environmental Engineering, Thu Dau Mot University, Binh Duong, Vietnam., Hoang LT; Department of Environmental Engineering, Thu Dau Mot University, Binh Duong, Vietnam., Dao MT; Department of Environmental Engineering, Thu Dau Mot University, Binh Duong, Vietnam., Hai-Nguyen; Institute of Fundamental and Applied Sciences, Duy Tan University, Ho Chi Minh City, Vietnam.; Faculty of Natural Sciences, Duy Tan University, Da Nang, Vietnam., Phan HV; Institute of Fundamental and Applied Sciences, Duy Tan University, Ho Chi Minh City, Vietnam.; Faculty of Natural Sciences, Duy Tan University, Da Nang, Vietnam., Yusuke H; Graduate School of Natural Science and Technology, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan., Mitsunaga T; Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan., Chavasiri W; Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand. warinthorn.c@chula.ac.th.
Jazyk: angličtina
Zdroj: Journal of natural medicines [J Nat Med] 2023 Mar; Vol. 77 (2), pp. 403-411. Date of Electronic Publication: 2023 Feb 07.
DOI: 10.1007/s11418-023-01681-2
Abstrakt: In the continuing discovery and structure elucidation of natural xanthone dimers, which are still rarely reported in absolute configuration, three new xanthone dimers, eumitrins I-K (1-3) were isolated from the lichen Usnea baileyi, a rich source of natural xanthone dimers. Their structures were elucidated unambiguously by spectroscopic analyses, including high-resolution electrospray ionization mass spectrometry (HRESIMS), 1D and 2D nuclear magnetic resonance spectroscopy (1D and 2D NMR). The absolute configuration of all three compounds was established through DP4 probability and ECD calculation. All compounds revealed weak activity for their enzymatic inhibition against α-glucosidase and tyrosinase, as well as antibacterial activity.
(© 2023. The Author(s) under exclusive licence to The Japanese Society of Pharmacognosy.)
Databáze: MEDLINE
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