Small anticancer drug release by light: Photochemical internalization of porphyrin-β-cyclodextrin nanoparticles.

Autor: Panagiotakis S; Institute of Nanoscience and Nanotechnology, National Center for Scientific Research 'Demokritos', Aghia Paraskevi 15341, Attiki, Greece. Electronic address: s.panagiotakis@inn.demokritos.gr., Mavroidi B; Institute of Biosciences & Applications, National Center for Scientific Research 'Demokritos', Aghia Paraskevi 15341, Attiki, Greece. Electronic address: bmavroidi@bio.demokritos.gr., Athanasopoulos A; Institute of Biosciences & Applications, National Center for Scientific Research 'Demokritos', Aghia Paraskevi 15341, Attiki, Greece. Electronic address: alexandr@bio.demokritos.gr., Gonçalves AR; Institute of Nanoscience and Nanotechnology, National Center for Scientific Research 'Demokritos', Aghia Paraskevi 15341, Attiki, Greece. Electronic address: aricardo7@gmail.com., Bugnicourt-Moreira L; University of Lyon, CNRS, UMR 5223, IMP, UCBL, 15 bd André Latarjet, F-69622 Villeurbanne, France. Electronic address: loic.bugnicourt@hotmail.com., Regagnon T; University of Lyon, CNRS, UMR 5223, IMP, UCBL, 15 bd André Latarjet, F-69622 Villeurbanne, France. Electronic address: tregagnon@hotmail.fr., Boukos N; Institute of Nanoscience and Nanotechnology, National Center for Scientific Research 'Demokritos', Aghia Paraskevi 15341, Attiki, Greece. Electronic address: n.boukos@inn.demokritos.gr., Charalambidis G; Laboratory of Bioinorganic Chemistry, Department of Chemistry, University of Crete, Voutes Campus, 70013 Heraklion, Crete, Greece. Electronic address: gcharal@uoc.gr., Coutsolelos AG; Laboratory of Bioinorganic Chemistry, Department of Chemistry, University of Crete, Voutes Campus, 70013 Heraklion, Crete, Greece. Electronic address: acoutsol@uoc.gr., Grigalavicius M; Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital - Radium Hospital, 0379 Oslo, Norway. Electronic address: mangri@rr-research.no., Theodossiou TA; Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital - Radium Hospital, 0379 Oslo, Norway. Electronic address: Theodossis.Theodossiou@rr-research.no., Berg K; Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital - Radium Hospital, 0379 Oslo, Norway. Electronic address: Kristian.Berg@rr-research.no., Ladavière C; University of Lyon, CNRS, UMR 5223, IMP, UCBL, 15 bd André Latarjet, F-69622 Villeurbanne, France. Electronic address: Catherine.Ladaviere@univ-lyon1.fr., Pelecanou M; Institute of Biosciences & Applications, National Center for Scientific Research 'Demokritos', Aghia Paraskevi 15341, Attiki, Greece. Electronic address: pelmar@bio.demokritos.gr., Yannakopoulou K; Institute of Nanoscience and Nanotechnology, National Center for Scientific Research 'Demokritos', Aghia Paraskevi 15341, Attiki, Greece. Electronic address: k.yannakopoulou@inn.demokritos.gr.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2023 Apr 15; Vol. 306, pp. 120579. Date of Electronic Publication: 2023 Jan 13.
DOI: 10.1016/j.carbpol.2023.120579
Abstrakt: Aiming to engineer simple, neutral, strongly amphiphilic photoactive nanoparticles (NPs) to specifically target cancer cell lysosomes for drug transport and light-controlled release, new conjugates of β-cyclodextrin with highly hydrophobic triphenylporphyrin bearing different alkyl chains, were synthesized. Although differently sized, all conjugates self-assemble into ~60 nm NPs in water and display similar photoactivity. The NPs target selectively the lysosomes of breast adenocarcinoma MCF-7 cells, embedding in vesicular membranes, as experiments with model liposomes indicate. Either empty or drug-loaded, the NPs lack dark toxicity for 48 h. They bind with differently structured anticancer drugs tamoxifen and gemcitabine as its N-adamantyl derivative. Red light irradiation of cells incubated with drug-loaded NPs results in major reduction of viability (>85 %) for 48 h displaying significant synergy of photo-chemotoxicity, as opposed to empty NPs, and to loaded non-irradiated NPs, in manifestation of photochemical internalization (PCI). Our approach expands the field of PCI into different small molecule chemotherapeutics.
Competing Interests: Declaration of competing interest There are no conflicts to declare.
(Copyright © 2023. Published by Elsevier Ltd.)
Databáze: MEDLINE
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