Association of hyponatremia with clinical outcomes in patients admitted with acute pulmonary embolism.

Autor: Deenadayalan V; Department of Internal Medicine, John H Stroger Hospital of Cook County, Chicago, IL, USA. vaishalideenadayalan99x@gmail.com., Karki S; Department of Internal Medicine, John H Stroger Hospital of Cook County, Chicago, IL, USA., Patel B; Department of Internal Medicine, John H Stroger Hospital of Cook County, Chicago, IL, USA., Kumi D; Department of Internal Medicine, John H Stroger Hospital of Cook County, Chicago, IL, USA., Zia M; Department of Hematology/Oncology, John H Stroger Hospital of Cook County, Chicago, IL, USA.
Jazyk: angličtina
Zdroj: Journal of thrombosis and thrombolysis [J Thromb Thrombolysis] 2023 May; Vol. 55 (4), pp. 737-741. Date of Electronic Publication: 2023 Feb 06.
DOI: 10.1007/s11239-023-02783-0
Abstrakt: Background: Hyponatremia is associated with negative prognosis in several conditions like Congestive heart failure and acute MI (Myocardial Infarction), but its impact on the outcomes in patients with pulmonary embolism (PE) is not well studied. We aimed to study the association of hyponatremia in patients hospitalized with PE.
Methods: A retrospective cohort study was designed using data obtained from the 2016 to 2019 combined National Inpatient Sample (NIS) database. Adult patients admitted with PE were identified and stratified based on the presence of hyponatremia. Primary outcomes assessed were, mortality, length of stay (LOS), and Total Hospitalization Charges (THC). Secondary outcomes included a diagnosis of Acute Kidney Injury (AKI), Acute Respiratory Failure (ARF), sepsis, Acute Cerebrovascular accident (CVA), arrhythmias and acute MI. Multivariate linear and logistic regressions were used to adjust for confounders.
Results: There was a total of 750,655 adult hospitalizations for PE and among them 41,595 (5.5%) had a secondary diagnosis of hyponatremia. Hyponatremia was associated with an increased odds of mortality, 6.31% vs 2.91% (AOR:1.77, p = 0.000, 95% CI: 1.61-1.92), increased LOS, 6.79 days vs 4.20 days (adjusted difference of 2.20 days, p = 0.000, 95% CI: 2.04-2.37), as well as an increase in THC, 75,458.95 USD vs 46,708.27 USD (adjusted difference of 24,341.37 USD, p < 0.001, 95% CI: 21,484.58-27,198.16). Similarly, the presence of hyponatremia was associated with increased odds of several secondary outcomes measured.
Conclusion: Hyponatremia is associated with an increased odds of death and attendant increase in LOS and THC. The odds of several secondary adverse clinical outcomes were also increased.
(© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze: MEDLINE
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