Tailorable and Biocompatible Supramolecular-Based Hydrogels Featuring two Dynamic Covalent Chemistries.

Autor: Marić I; Stratingh Institute, Centre for Systems Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen (The, Netherlands.; Dutch Polymer Institute, P. O. Box 902, 5600 AX, Eindhoven (The, Netherlands., Yang L; University Medical Center Groningen, Department of Biomedical Engineering-FB40 and W. J. Kolff Institute for Biomedical Engineering and Materials Science-FB41, University of Groningen, A. Deusinglaan 1, 9713 AV, Groningen (The, Netherlands., Li X; Physical Chemistry and Soft Matter, Wageningen University, Stippeneng 4, 6708 WE, Wageningen (The, Netherlands., Santiago GM; Stratingh Institute, Centre for Systems Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen (The, Netherlands., Pappas CG; Stratingh Institute, Centre for Systems Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen (The, Netherlands., Qiu X; Stratingh Institute and Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands., Dijksman JA; Physical Chemistry and Soft Matter, Wageningen University, Stippeneng 4, 6708 WE, Wageningen (The, Netherlands., Mikhailov K; Stratingh Institute, Centre for Systems Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen (The, Netherlands., van Rijn P; University Medical Center Groningen, Department of Biomedical Engineering-FB40 and W. J. Kolff Institute for Biomedical Engineering and Materials Science-FB41, University of Groningen, A. Deusinglaan 1, 9713 AV, Groningen (The, Netherlands., Otto S; Stratingh Institute, Centre for Systems Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen (The, Netherlands.
Jazyk: angličtina
Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2023 Mar 27; Vol. 62 (14), pp. e202216475. Date of Electronic Publication: 2023 Feb 24.
DOI: 10.1002/anie.202216475
Abstrakt: Dynamic covalent chemistry (DCC) has proven to be a valuable tool in creating fascinating molecules, structures, and emergent properties in fully synthetic systems. Here we report a system that uses two dynamic covalent bonds in tandem, namely disulfides and hydrazones, for the formation of hydrogels containing biologically relevant ligands. The reversibility of disulfide bonds allows fiber formation upon oxidation of dithiol-peptide building block, while the reaction between NH-NH 2 functionalized C-terminus and aldehyde cross-linkers results in a gel. The same bond-forming reaction was exploited for the "decoration" of the supramolecular assemblies by cell-adhesion-promoting sequences (RGD and LDV). Fast triggered gelation, cytocompatibility and ability to "on-demand" chemically customize fibrillar scaffold offer potential for applying these systems as a bioactive platform for cell culture and tissue engineering.
(© 2023 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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