Could α MSH-MIFT Axis and IDH2 be Considered Promising Predictors of Non-segmental Vitiligo Response to NB-UVB Phototherapy?

Autor: Monib KME; Drs. Monib and Sorour are Professors of Dermatology and Andrology, Faculty of Medicine at Benha University in Benha, Egypt., Sorour NE; Drs. Monib and Sorour are Professors of Dermatology and Andrology, Faculty of Medicine at Benha University in Benha, Egypt., Alhusseini NF; Dr. Alhusseini is a Professor of Medical Biochemistry and Molecular Biology, Faculty of Medicine at Benha University in Benha, Egypt., Abdou AG; Dr. Abdou is a Professor of Pathology, Faculty of Medicine at Menoufia University, Egypt., Yousif A; Dr. Yousif is a Lecturer of Dermatology and Andrology, Faculty of Medicine at Benha University in Benha, Egypt., Salem RM; Dr. Salem is an Assistant Professor of Dermatology and Andrology, Faculty of Medicine at Benha University in Benha, Egypt.
Jazyk: angličtina
Zdroj: The Journal of clinical and aesthetic dermatology [J Clin Aesthet Dermatol] 2023 Jan; Vol. 16 (1), pp. 41-46.
Abstrakt: Background: The search for objective factors that help in predicting the response of vitiligo treatment is very important.
Objective: We sought to evaluate the effect of NB-UVB phototherapy on both the alpha melanocyte stimulating hormone-microphthalmia-associated transcription factor (α-MSH-MIFT) axis, and isocitrate dehydrogenase 2 (IDH2) in non-segmental vitiligo (NSV).
Methods: This prospective clinical trial included 50 NSV patients and 50 healthy control subjects. α-MSH tissue levels as well as MITF and IDH2 immunostaining were assessed in normal and vitiliginous skin biopsies before treatment and then in the repigmented areas following 24 NB-UVB phototherapy treatment sessions using ELISA technique and immunohistochemical study, respectively.
Results: There was a significant negative correlation between baseline VASI scores and the tissue levels of α-MSH ( p =0.006) and the expression of both MITF ( p <0.00001) and IDH-2 ( p = 0.001). The mean α-MSH tissue levels increased significantly after treatment ( p <0.001). Tissue expression of both MTIF and IDH-2 was significantly upregulated following treatment ( P -value <0.001). The percentage of improvement showed a significant positive correlation with the studied markers ( p <0.00001).
Conclusion: α-MSH- MIFT axis and the antioxidant protein IDH2 are promising objective markers of non-segmental vitiligo severity, and are suggested as predictors of vitiligo response to treatment.
Competing Interests: DISCLOSURES: The authors report no conflicts of interest relevant to the content of this article.
(Copyright © 2023. Matrix Medical Communications. All rights reserved.)
Databáze: MEDLINE
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