The Effectiveness of SARS-CoV-2 Vaccination in Preventing Severe Illness and Death - Real-world Data from a Cohort of Patients Hospitalized with COVID-19.

Autor: Sagiraju HKR; Department of Preventive Oncology, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Elavarasi A; Department of Neurology, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Gupta N; Department of Onco-Anesthesia and Palliative Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Garg RK; Department of Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Paul SS; Department of Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Vig S; Department of Onco-Anesthesia and Palliative Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Sirohiya P; Department of Onco-Anesthesia and Palliative Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Ratre B; Department of Onco-Anesthesia and Palliative Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Garg R; Department of Onco-Anesthesia and Palliative Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Pandit A; Department of Onco-Anesthesia and Palliative Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Singh R; Department of Onco-Anesthesia and Palliative Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Kumar B; Department of Onco-Anesthesia and Palliative Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Meena VP; Department of Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Wig N; Department of Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Mittal S; Pulmonary Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Pahuja S; Pulmonary Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Madan K; Pulmonary Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Das N; Department of Laboratory Oncology, All India Institute of Medical Sciences, New Delhi, India., Dwivedi T; Department of Laboratory Oncology, All India Institute of Medical Sciences, New Delhi, India., Gupta R; Department of Laboratory Oncology, All India Institute of Medical Sciences, New Delhi, India., Wundavalli L; Department of Hospital Administration, All India Institute of Medical Sciences, New Delhi, India., Singh AR; Department of Hospital Administration, All India Institute of Medical Sciences, New Delhi, India., Singh S; Department of Hospital Administration, All India Institute of Medical Sciences, New Delhi, India., Mishra A; Department of Onco-Anesthesia and Palliative Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Pandey M; Department of Onco-Anesthesia and Palliative Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Matharoo KS; Department of Onco-Anesthesia and Palliative Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Kumar S; Department of Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India., Mohan A; Pulmonary Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Guleria R; Pulmonary Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India., Bhatnagar S; Department of Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India.
Jazyk: angličtina
Zdroj: Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine [Indian J Community Med] 2022 Oct-Dec; Vol. 47 (4), pp. 510-516. Date of Electronic Publication: 2022 Dec 14.
DOI: 10.4103/ijcm.ijcm_1388_21
Abstrakt: Background: While long-term studies on the correlates of protection, vaccine effectiveness, and enhanced surveillance are awaited for SARS-CoV-2 vaccine, studies on breakthrough infections help understand the nature and course of this illness among vaccinated individuals and guide in public health preparedness. This study aims to compare the differences in the hospitalization outcomes SARS-CoV-2 infection of fully vaccinated individuals with with those of unvaccinated and partially vaccinated individuals.
Materials and Methods: Single institution observational cohort study. This study compared the differences in clinical, biochemical parameters and the hospitalization outcomes of 53 fully vaccinated individuals with those of unvaccinated (1464) and partially vaccinated (231) individuals, among a cohort of 2,080 individuals hospitalized with SARS-CoV-2 infection. Descriptive statistics and propensity-score weighted multivariate logistic regression analysis adjusting for clinical and laboratory parameters were used to compare the differences and to identify factors associated with outcomes.
Results: Completing the course of vaccination protected individuals from developing severe COVID-19 as evidenced by lower proportions of those with hypoxia, abnormal levels of inflammatory markers, requiring ventilatory support, and death compared to unvaccinated and partially vaccinated individuals. There were no differences in these outcomes among patients who received either vaccine type approved in India.
Conclusions: Efforts should be made to improve the vaccination rates as a timely measure to prepare for the upcoming waves of this highly transmissible pandemic. Vaccination rates of the communities may also guide in the planning of the health needs and appropriate use of medical resources.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2022 Indian Journal of Community Medicine.)
Databáze: MEDLINE
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