KIT (CD117) Positive Huge Primary Malignant Extra Gastrointestinal Stromal Tumors (EGISTs) Arising From Jejunal Mesentery: A Rare Case Report.
| Autor: | Sajjanar AB; Pathology, Datta Meghe Medical College, Datta Meghe Institute of Medical Sciences, Nagpur, IND., Katole NT; Pharmacology and Therapeutics, Datta Meghe Medical College, Datta Meghe Institute of Medical Sciences, Nagpur, IND., Vagha SJ; Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2022 Dec 31; Vol. 14 (12), pp. e33168. Date of Electronic Publication: 2022 Dec 31 (Print Publication: 2022). |
| DOI: | 10.7759/cureus.33168 |
| Abstrakt: | Tumors arising outside gastrointestinal systems are known as extra gastrointestinal stromal tumors (EGISTs). Outside gastrointestinal sites include the mesentery, omentum, peritoneum, pancreas, and liver. Our case highlights a rare occurrence of an EGIST in jejunal mesentery in a 45-year-old male with an asymptomatic large abdominal growth and weight loss. A contrast-enhanced multi-dimensional computed tomography scan showed a large heterogeneous mass in the left hypochondrium. lumbar, and paraumbilical regions. Later, the patient underwent surgical resection of the tumor along with the involved jejunal segment and small tumor masses in the mesentery. Histopathological examination reported a malignant EGIST of mesentery and invasion into the jejunum, further confirmed by immunohistochemistry (IHC) markers like CD117 and smooth muscle actin with a high proliferative index (Ki67). One should be aware that these are different from other malignancies arising from the mesentery. Their cell of origin is different and needs a specific type of treatment. The clinical history, radiological findings, histopathology, and IHC help in diagnosing especially when they are arising from unusual areas like jejunal mesentery. Surgical intervention and chemotherapy are mainstay treatments. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Sajjanar et al.) |
| Databáze: | MEDLINE |
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