Single-agent chemotherapy in low-risk gestational trophoblastic neoplasia.
| Autor: | Mousavi Seresht L; Department of Gynecology and Oncology, Isfahan University of Medical Sciences, Isfahan, Iran., Farazestanian M; Department of Gynecology and Oncology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran., Yousefi Z; Department of Gynecology and Oncology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. |
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| Jazyk: | angličtina |
| Zdroj: | Caspian journal of internal medicine [Caspian J Intern Med] 2023 Winter; Vol. 14 (1), pp. 108-111. |
| DOI: | 10.22088/cjim.14.1.108 |
| Abstrakt: | Background: Low-risk gestational trophoblastic neoplasia could be cured in the case of appropriate management with single-agent chemotherapy. This study was carried out to compare the efficacy of single-dose methotrexate versus Actinomycin-D in low-risk gestational trophoblastic neoplasia to analyze the most effective agent. Methods: This retrospective cohort study was conducted on the medical record of 170 cases with the diagnosis of low-risk gestational trophoblastic neoplasia from 2012 to 2019 to evaluate the response rate of single-dose weekly-methotrexate versus biweekly-Actinomycin-D. Results: Single agent chemotherapy was required in 170 patients with final risk score of less than 7. Among the 100 cases under weekly-methotrexate therapy, 29 patients were required second-line chemotherapy with Actinomycin-D and combination therapy which means complete remission of 71% with methotrexate, in comparison with 78.5% in the other group. Resistance was mostly seen in patients with documented choriocarcinoma in histology who had not received timely diagnosis and treatment. Conclusion: Individualized decision in the management of low-risk gestational trophoblastic neoplasia cases, based on histology, HCG, and history is the corn stone in successful treatment. Competing Interests: The authors declare that no funds, grants, or other support were received during the preparation of this manuscript. |
| Databáze: | MEDLINE |
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