An RF coil design to enable quintuple nuclear whole-brain MRI.

Autor: Dai J; University Medical Center Utrecht, Utrecht, The Netherlands.; Tesla Dynamic Coils B.V., Zaltbommel, The Netherlands., Gosselink M; University Medical Center Utrecht, Utrecht, The Netherlands., van der Velden TA; University Medical Center Utrecht, Utrecht, The Netherlands., Meliadò EF; University Medical Center Utrecht, Utrecht, The Netherlands.; Tesla Dynamic Coils B.V., Zaltbommel, The Netherlands., Raaijmakers AJE; University Medical Center Utrecht, Utrecht, The Netherlands.; Eindhoven University of Technology, Eindhoven, The Netherlands., Klomp DWJ; University Medical Center Utrecht, Utrecht, The Netherlands.
Jazyk: angličtina
Zdroj: Magnetic resonance in medicine [Magn Reson Med] 2023 May; Vol. 89 (5), pp. 2131-2141. Date of Electronic Publication: 2023 Feb 05.
DOI: 10.1002/mrm.29577
Abstrakt: Purpose: To bring metabolic imaging based on multi-NMR toward practical use from the RF hardware perspective.
Methods: A highly integrated RF coil is designed for whole-brain MRI and MRS targeted to five nuclear species: 1 H, 19 F, 31 P, 23 Na, and 13 C. Dipole antennas and closely loaded local receiver loops are combined in this setup.
Results: High-quality in vivo scan results of 1 H, 31 P, 23 Na, and 13 C on healthy volunteers have been achieved. For 1 H, the transmit efficiency is 77% of a single-tuned commercial head coil (NOVA 8-transmit [Tx]/32-receive [Rx]; NOVA Medical, Wilmington, MA, USA). For 31 P, 110% SNR of a dual-tuned close-fit head-birdcage was achieved at the center of the subject, based on MR experiments on a phantom. For 31 P, 23 Na, and 13 C, bench measurements indicate SNR loss of 15%, 27%, and 30% compared with single-tuned conditions. 19 F performance has been proven to be similar to that of 1 H through bench tests and electromagnetic simulations.
Conclusion: With this device, 1 H-based anatomic images that are expected to meet clinical requirements, as well as high-quality multi-NMR images and spectra, can be acquired within one scan session without hardware replacement or patient repositioning, enabling morphologic and metabolic MRI within acceptable scan time.
(© 2023 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)
Databáze: MEDLINE
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