Diagnostic Value of Adding Magnifying Chromoendoscopy to Magnifying Narrow-Band Imaging Endoscopy for Colorectal Polyps.

Autor:	Matsumura T; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address: matsumura@chiba-u.jp., Ebigbo A; Department of Gastroenterology, Universitätsklinikum Augsburg, Augsburg, Germany., Römmele C; Department of Gastroenterology, Universitätsklinikum Augsburg, Augsburg, Germany., Ikematsu H; Division of Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan., Ishigami H; Department of Gastroenterology, Chiba Rosai Hospital, Chiba, Japan., Suzuki T; Endoscopy Division, Chiba Cancer Center, Chiba, Japan., Harada H; Department of Gastroenterology, New Tokyo Hospital, Chiba, Japan., Yada T; Division of Gastroenterology and Hepatology, Kohnodai Hospital, National Center for Global Health and Medicine, Chiba, Japan., Takatori Y; Division of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Tokyo, Japan., Takeuchi M; Division of Gastroenterology and Hepatology, Nagaoka Red Cross Hospital, Nagaoka, Japan., Okimoto K; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan., Akizue N; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan., Maruoka D; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan., Kitagawa Y; Endoscopy Division, Chiba Cancer Center, Chiba, Japan., Minamide T; Division of Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan., Iwaki T; Department of Gastroenterology, New Tokyo Hospital, Chiba, Japan., Amano Y; Department of Gastroenterology, New Tokyo Hospital, Chiba, Japan., Matsusaka K; Department of Pathology, Chiba University Hospital, Chiba, Japan., Nagashima K; Biostatistics Unit, Clinical and Translational Research Center, Keio University Hospital, Tokyo, Japan., Maehata T; Division of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Tokyo, Japan., Yahagi N; Division of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Tokyo, Japan., Messmann H; Department of Gastroenterology, Universitätsklinikum Augsburg, Augsburg, Germany., Kato N; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Jazyk:	angličtina
Zdroj:	Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2023 Sep; Vol. 21 (10), pp. 2551-2559.e2. Date of Electronic Publication: 2023 Feb 03.
DOI:	10.1016/j.cgh.2023.01.028
Abstrakt:	Background & Aims: This study examined the additional value of magnifying chromoendoscopy (MCE) on magnifying narrow-band imaging endoscopy (M-NBI) in the optical diagnosis of colorectal polyps. Methods: A multicenter prospective study was conducted at 9 facilities in Japan and Germany. Patients with colorectal polyps scheduled for resection were included. Optical diagnosis was performed by M-NBI first, followed by MCE. Both diagnoses were made in real time. MCE was performed on all type 2B lesions classified according to the Japan NBI Expert Team classification and other lesions at the discretion of endoscopists. The diagnostic accuracy and confidence of M-NBI and MCE for colorectal cancer (CRC) with deep invasion (≥T1b) were compared on the basis of histologic findings after resection. Results: In total, 1173 lesions were included between February 2018 and December 2020, with 654 (5 hyperplastic polyp/sessile serrated lesion, 162 low-grade dysplasia, 403 high-grade dysplasia, 97 T1 CRCs, and 32 ≥T2 CRCs) examined using MCE after M-NBI. In the diagnostic accuracy for predicting CRC with deep invasion, sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for M-NBI were 63.1%, 94.2%, 61.6%, 94.5%, and 90.2%, respectively, and for MCE they were 77.4%, 93.2%, 62.5%, 96.5%, and 91.1%, respectively. The sensitivity was significantly higher in MCE (P < .001). However, these additional values were limited to lesions with low confidence in M-NBI or the ones diagnosed as ≥T1b CRC by M-NBI. Conclusions: In this multicenter prospective study, we demonstrated the additional value of MCE on M-NBI. We suggest that additional MCE be recommended for lesions with low confidence or the ones diagnosed as ≥T1b CRC. Trials registry number: UMIN000031129. (Copyright © 2023 AGA Institute. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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