NRF2 signaling pathway: A comprehensive prognostic and gene expression profile analysis in breast cancer.

Autor: Soghli N; Babol University of Medical Sciences, Faculty of Dentistry, Babol, Iran., Yousefi H; Louisiana State University Health Science Center (LSUHSC), Biochemistry & Molecular Biology, New Orleans, LA, USA; Stanley S. Scott Cancer Research Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Naderi T; Department of Laboratory Hematology and Blood Bank, School of Allied Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Fallah A; Department of hematology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran., Moshksar A; University of Texas Medical Branch (UTMB), Interventional Radiology, Galveston, TX, USA., Darbeheshti F; Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Vittori C; Stanley S. Scott Cancer Research Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Delavar MR; Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran., Zare A; Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Rad HS; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia., Kazemi A; Fasa University of Medical Sciences, School of Medicine, Fasa, Iran., Bitaraf A; Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran., Hussen BM; Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, Iraq., Taheri M; Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Institute of Human Genetics, Jena University Hospital, Jena, Germany. Electronic address: mohammad.taheri@uni-jena.de., Jamali E; Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: elena.jamali@yahoo.com.
Jazyk: angličtina
Zdroj: Pathology, research and practice [Pathol Res Pract] 2023 Mar; Vol. 243, pp. 154341. Date of Electronic Publication: 2023 Jan 24.
DOI: 10.1016/j.prp.2023.154341
Abstrakt: Breast cancer is the most frequently diagnosed malignant tumor in women and a major public health concern. NRF2 axis is a cellular protector signaling pathway protecting both normal and cancer cells from oxidative damage. NRF2 is a transcription factor that binds to the gene promoters containing antioxidant response element-like sequences. In this report, differential expression of NRF2 signaling pathway elements, as well as the correlation of NRF2 pathway mRNAs with various clinicopathologic characteristics, including molecular subtypes, tumor grade, tumor stage, and methylation status, has been investigated in breast cancer using METABRIC and TCGA datasets. In the current report, our findings revealed the deregulation of several NRF2 signaling elements in breast cancer patients. Moreover, there were negative correlations between the methylation of NRF2 genes and mRNA expression. The expression of NRF2 genes significantly varied between different breast cancer subtypes. In conclusion, substantial deregulation of NRF2 signaling components suggests an important role of these genes in breast cancer. Because of the clear associations between mRNA expression and methylation status, DNA methylation could be one of the mechanisms that regulate the NRF2 pathway in breast cancer. Differential expression of Hippo genes among various breast cancer molecular subtypes suggests that NRF2 signaling may function differently in different subtypes of breast cancer. Our data also highlights an interesting link between NRF2 components' transcription and tumor grade/stage in breast cancer.
Competing Interests: Conflict of interest The authors declare they have no conflict of interest.
(Copyright © 2023 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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