| Autor: |
Abacı N; Department of Pharmacognosy, Gazi University, Faculty of Pharmacy, Ankara, Türkiye., Senol Deniz FS; Department of Pharmacognosy, Gazi University, Faculty of Pharmacy, Ankara, Türkiye., Ekhteiari Salmas R; Department of Chemistry, King's College London, Britannia House, London, UK., Uysal Bayar F; Department of Food Technology, Bati Akdeniz Agricultural Research Institute, Medicinal and Aromatic Plants, Antalya, Türkiye., Turgut K; Department of Field Crops, Akdeniz University, Faculty of Agriculture, Antalya, Türkiye., Orhan IE; Department of Pharmacognosy, Gazi University, Faculty of Pharmacy, Ankara, Türkiye.; Principal Member of Turkish Academy of Sciences (TÜBA), Ankara, Türkiye. |
| Abstrakt: |
The EtOH extracts of the leaves of two new cultivars (Uysal-SFU and Turgut-SFT) of Salvia fruticosa Mill. was tested against acetylcholinesterase (IC50: 30.62 ± 3.27 and 32.97 ± 2.33 µg/mL for SFU and SFT, respectively) and butyrylcholinesterase (IC50: 69.91 ± 1.08 µg/mL and 86.55 ± 1.26 µg/mL), respectively, relevant to Alzheimer's disease. The essential oils showed a stumpy inhibition against AChE and no inhibition against BChE. DPPH radical scavenging activity of the extracts (86.70 ± 0.17% and 86.14 ± 1.13% for SFU and SFT, respectively) was stronger than that of quercetin (85.51 ± 0.17%): Their (1.24 ± 0.05 and 1.04 ± 0.16 for SFU and SFT, respectively) ferric-reducing antioxidant power were close to that of the reference (e.g. quercetin, 1.42 ± 0.14). Molecular docking simulations were performed on their major monoterpenes. Our findings revealed that the leaf EtOH extracts of two cultivars are promising inhibitors of both AChE and BChE. |
