Diet quality, food intake and incident adult-onset asthma: a Lifelines Cohort Study.

Autor: Visser E; Department of Epidemiology, Medical Centre Leeuwarden, Leeuwarden, The Netherlands. edith.visser@mcl.nl.; Department of Sustainable Health, Faculty Campus Fryslân, University of Groningen, Leeuwarden, The Netherlands. edith.visser@mcl.nl., de Jong K; Department of Epidemiology, Medical Centre Leeuwarden, Leeuwarden, The Netherlands., Pepels JJS; Department of Epidemiology, Medical Centre Leeuwarden, Leeuwarden, The Netherlands., Kerstjens HAM; Department of Pulmonary Medicine, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands., Ten Brinke A; Department of Pulmonary Medicine, Medical Centre Leeuwarden, Leeuwarden, The Netherlands., van Zutphen T; Department of Sustainable Health, Faculty Campus Fryslân, University of Groningen, Leeuwarden, The Netherlands.
Jazyk: angličtina
Zdroj: European journal of nutrition [Eur J Nutr] 2023 Jun; Vol. 62 (4), pp. 1635-1645. Date of Electronic Publication: 2023 Feb 04.
DOI: 10.1007/s00394-023-03091-2
Abstrakt: Purpose: Dietary factors have been suggested as drivers of the rising prevalence of adult-onset asthma, but evidence is inconclusive, possibly due to the complex interrelation with obesity. We aim to explore the relation of diet quality and food intake with incident adult-onset asthma in normal weight and overweight adults of the prospective population-based Lifelines Cohort Study.
Methods: Incident adult-onset asthma was defined as self-reported asthma at ± 4-year follow-up, in adults free of airway disease at baseline. Diet quality scores and food group intake were assessed at baseline. Log-binomial regression analyses were used to estimate adjusted relative risks (RR) between dietary intake (per portion) and incident adult-onset asthma, in categories of BMI (cutoff: 25 kg/m 2 ).
Results: 477 incident asthma cases (75% female, 62% overweight) and 34,698 controls (60% female, 53% overweight) were identified. Diet quality-assessed by the Lifelines Diet Score and Mediterranean Diet Score-was not associated with incident adult-onset asthma in the two BMI groups. Although the dietary intake of several food groups differed between cases and controls, after adjustment for confounders only few remained associated with adult-onset asthma, including red and processed meat (RR: 0.93 per 15 g intake; 95% CI 0.86-0.99) in the normal weight group and intake of cheese (RR 1.09 per 20 g intake; 95% CI 1.00-1.17) and vegetables (RR 1.10 per 50 g intake; 95% CI 1.00-1.21) in the overweight group.
Conclusion: The results of this study question the role of food as a 'simple' predictor of adult-onset asthma and call for an integrative approach, including a range of modifiable lifestyle factors and further asthma phenotyping.
(© 2023. The Author(s).)
Databáze: MEDLINE
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