Rare case of anti-CV2 paraneoplastic polyneuropathy associated with lung adenocarcinoma.

Autor:	Lizwan M; Duke-NUS Medical School, Singapore., Lin SZZ; Department of Neurology, National Neuroscience Institute - Singapore General Hospital Campus, Singapore., Sonu SK; Department of Neurology, National Neuroscience Institute - Singapore General Hospital Campus, Singapore maithalimunda@gmail.com.
Jazyk:	angličtina
Zdroj:	BMJ case reports [BMJ Case Rep] 2023 Feb 03; Vol. 16 (2). Date of Electronic Publication: 2023 Feb 03.
DOI:	10.1136/bcr-2022-253686
Abstrakt:	We describe the first case of anti-CV2 paraneoplastic polyneuropathy associated with lung adenocarcinoma. Our patient presented with progressive unsteadiness and numbness involving bilateral upper and lower limbs. He had symmetrical length-dependent lower motor neuron pattern of weakness and numbness involving both small and large fibres with prominent sensory ataxia. An extended workup for the polyneuropathy involving a serum paraneoplastic antineuronal antibody panel showed a positive reaction for anti-CV2 antibody. CT scan of the thorax, abdomen and pelvis revealed a right upper lung nodule and histopathological examination of the nodule revealed lung adenocarcinoma. He was scheduled for chemotherapy following his discharge and there was improvement of his sensorimotor polyneuropathy following his chemotherapy. Competing Interests: Competing interests: None declared. (© BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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