Consequences of Shigella infection in young children: a systematic review.

Autor:	Libby TE; Department of Epidemiology, University of Washington, Seattle, Washington, USA. Electronic address: libbyte@uw.edu., Delawalla MLM; Department of Epidemiology, University of Washington, Seattle, Washington, USA., Al-Shimari F; Department of Global Health, University of Washington, Seattle, Washington, USA., MacLennan CA; Bill and Melinda Gates Foundation, London, UK., Vannice KS; Bill and Melinda Gates Foundation, Seattle, Washington, USA., Pavlinac PB; Department of Global Health, University of Washington, Seattle, Washington, USA.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2023 Apr; Vol. 129, pp. 78-95. Date of Electronic Publication: 2023 Jan 31.
DOI:	10.1016/j.ijid.2023.01.034
Abstrakt:	Objectives: We conducted a systematic review of the longitudinal consequences of Shigella infection in children to inform the value proposition for an effective vaccine. Methods: We searched PubMed and Embase for studies published from January 01, 1980 to December 12, 2022 and conducted in low- and middle-income countries that included longitudinal follow-up after Shigella detection among children aged <5 years, irrespective of language. We collected data on all outcomes subsequent to Shigella detection, except mortality. Results: Of 2627 papers identified, 52 met inclusion criteria. The median sample size of children aged <5 years was 66 (range 5-2172). Data were collected in 20 countries; 56% (n = 29) of the publications included Bangladesh. The most common outcomes related to diarrhea (n = 20), linear growth (n = 14), and the mean total cost of a Shigella episode (n = 4; range: $ 6.22-31.10). Among children with Shigella diarrhea, 2.9-61.1% developed persistent diarrhea (≥14 days); the persistence was significantly more likely among children who were malnourished, had bloody stool, or had multidrug-resistant Shigella. Cumulative Shigella infections over the first 2 years of life contributed to the greatest loss in length-for-age z-score. Conclusion: We identified evidence that Shigella is associated with persistent diarrhea, linear growth faltering, and economic impact to the family. Competing Interests: Declaration of interests The authors have no competing interests to declare. (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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