Vaccine hesitancy decreases in rheumatic diseases, long-term concerns remain in myositis: a comparative analysis of the COVAD surveys.

Autor:	Sen P; Maulana Azad Medical College, New Delhi, Delhi, India., R N; Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India., Houshmand N; Department of Internal Medicine, Kirk Kerkorian School of Medicine, University of Nevada Las Vegas, Las Vegas, NV, USA., Moghadam Kia S; Myositis Center and Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Joshi M; Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune, India., Saha S; Mymensingh Medical College, Mymensingh, Bangladesh., Jagtap K; Seth Gordhandhas Sunderdas Medical College and King Edwards Memorial Hospital, Mumbai, Maharashtra, India., Agarwal V; Mahatma Gandhi Mission Medical College, Navi Mumbai, Maharashtra, India., Nune A; Southport and Ormskirk Hospital NHS Trust, Southport, UK., Nikiphorou E; Centre for Rheumatic Diseases, King's College London, London, UK.; Rheumatology Department, King's College Hospital, London, UK., Tan AL; NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK.; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK., Shinjo SK; Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Ziade N; Rheumatology Department, Saint-Joseph University, Beirut, Lebanon.; Rheumatology Department, Hotel-Dieu de France Hospital, Beirut, Lebanon., Velikova T; Medical Faculty, Sofia University St. Kliment Ohridski, Sofia, Bulgaria., Milchert M; Department of Internal Medicine, Rheumatology, Diabetology, Geriatrics and Clinical Immunology, Pomeranian Medical University, Szczecin, Poland., Parodis I; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.; Department of Rheumatology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Gracia-Ramos AE; Department of Internal Medicine, General Hospital, National Medical Center 'La Raza', Instituto Mexicano del Seguro Social, Mexico City, Mexico., Cavagna L; Rheumatology Unit, Dipartimento di Medicine Interna e Terapia Medica, Università degli studi di Pavia, Pavia, Lombardy, Italy., Kuwana M; Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan., Knitza J; Medizinische Klinik 3-Rheumatologie und Immunologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Deutschland., Makol A; Division of Rheumatology, Mayo Clinic, Rochester, MN, USA., Patel A; Bon Secours Rheumatology Center and Division of Pediatric Rheumatology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA., Pauling JD; Bristol Medical School Translational Health Sciences, University of Bristol, UK.; Department of Rheumatology, North Bristol NHS Trust, Bristol, UK., Wincup C; Department of Rheumatology, Division of Medicine, Rayne Institute, University College London, UK.; Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCLH, GOSH, London, UK., Barman B; Department of General Medicine, All India Institute of Medical Sciences (AIIMS), Guwahati, India., Zamora Tehozol EA; Rheumatology, Medical Care & Research, Centro Medico Pensiones Hospital, Instituto Mexicano del Seguro Social Delegación Yucatán, Yucatán, Mexcio., Rojas Serrano J; Rheumatologist and Clinical Investigator, Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico., García-De La Torre I; Departamento de Inmunología y Reumatología, Hospital General de Occidente and Universidad de Guadalajara, Guadalajara, Jalisco, Mexico., Colunga-Pedraza IJ; Rheumatology, Hospital Universitario Dr Jose Eleuterio Gonzalez, Monterrey, Mexico., Merayo-Chalico J; Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Chibuzo OC; Department of Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla/University of Nigeria, Enugu, Nigeria., Katchamart W; Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Akawatcharangura Goo P; Department of Medicine, Queen Savang Vadhana Memorial Hospital, Chonburi, Thailand., Shumnalieva R; Department of Rheumatology, Clinic of Rheumatology, University Hospital 'St. Ivan Rilski', Medical University-Sofia, Bulgaria., Chen YM; Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan.; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan., Hoff LS; School of Medicine, Universidade Potiguar (UnP), Natal, Brazil., El Kibbi L; Rheumatology Unit, Internal Medicine Department, Specialized Medical Center, Riyadh, Saudi Arabia., Halabi H; Department of Internal Medicine, Section of Rheumatology, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia., Vaidya B; National Center for Rheumatic Diseases (NCRD), Kathmandu, Nepal., Sazliyana Shaharir S; Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia., Hasan ATMT; Department of Rheumatology, Enam Medical College & Hospital, Dhaka, Bangladesh., Dey D; Rheumatology Unit, Department of Medicine and Therapeutics, University of Ghana Medical School, College of Health Sciences, Accra, Ghana., Gutiérrez CET; Reference Center for Osteoporosis, Rheumatology and Dermatology, Pontifica Universidad Javeriana Cali, Colombia., Caballero-Uribe CV; Department of Medicine, Hospital Universidad del Norte, Barranquilla, Atlantico, Colombia., Lilleker JB; Division of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre The University of Manchester, Manchester, UK.; Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, Salford, UK., Salim B; Rheumatology Department, Fauji Foundation Hospital, Rawalpindi, Pakistan., Gheita T; Rheumatology Department, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt., Chatterjee T; Department of Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, USA., Distler O; Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Saavedra MA; Departamento de Reumatología Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico Nacional La Raza, IMSS, Mexico City, Mexico., Day J; Department of Rheumatology, Royal Melbourne Hospital, Parkville, VIC, Australia.; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC , Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Chinoy H; Division of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre The University of Manchester, Manchester, UK.; National Institute for Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, The University of Manchester, Manchester, UK.; Department of Rheumatology, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK., Agarwal V; Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India., Aggarwal R; Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Gupta L; Division of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre The University of Manchester, Manchester, UK.; Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK.; City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
Jazyk:	angličtina
Zdroj:	Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2023 Oct 03; Vol. 62 (10), pp. 3291-3301.
DOI:	10.1093/rheumatology/kead057
Abstrakt:	Objective: COVID-19 vaccines have a favorable safety profile in patients with autoimmune rheumatic diseases (AIRDs) such as idiopathic inflammatory myopathies (IIMs); however, hesitancy continues to persist among these patients. Therefore, we studied the prevalence, predictors and reasons for hesitancy in patients with IIMs, other AIRDs, non-rheumatic autoimmune diseases (nrAIDs) and healthy controls (HCs), using data from the two international COVID-19 Vaccination in Autoimmune Diseases (COVAD) e-surveys. Methods: The first and second COVAD patient self-reported e-surveys were circulated from March to December 2021, and February to June 2022 (ongoing). We collected data on demographics, comorbidities, COVID-19 infection and vaccination history, reasons for hesitancy, and patient reported outcomes. Predictors of hesitancy were analysed using regression models in different groups. Results: We analysed data from 18 882 (COVAD-1) and 7666 (COVAD-2) respondents. Reassuringly, hesitancy decreased from 2021 (16.5%) to 2022 (5.1%) (OR: 0.26; 95% CI: 0.24, 0.30, P < 0.001). However, concerns/fear over long-term safety had increased (OR: 3.6; 95% CI: 2.9, 4.6, P < 0.01). We noted with concern greater skepticism over vaccine science among patients with IIMs than AIRDs (OR: 1.8; 95% CI: 1.08, 3.2, P = 0.023) and HCs (OR: 4; 95% CI: 1.9, 8.1, P < 0.001), as well as more long-term safety concerns/fear (IIMs vs AIRDs - OR: 1.9; 95% CI: 1.2, 2.9, P = 0.001; IIMs vs HCs - OR: 5.4 95% CI: 3, 9.6, P < 0.001). Caucasians [OR 4.2 (1.7-10.3)] were likely to be more hesitant, while those with better PROMIS physical health score were less hesitant [OR 0.9 (0.8-0.97)]. Conclusion: Vaccine hesitancy has decreased from 2021 to 2022, long-term safety concerns remain among patients with IIMs, particularly in Caucasians and those with poor physical function. (© The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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