Development of a theranostic preclinical fluorescence molecular tomography/cone beam CT-guided irradiator platform.

Autor:	Nouizi F; Tu and Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California Irvine, CA 92697, USA.; Chao Family Comprehensive Cancer Center, University of California Irvine, CA 92697, USA., Brooks J; Department of Radiation Oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA., Zuro DM; Department of Radiation Oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA., Hui SK; Department of Radiation Oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA., Gulsen G; Tu and Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California Irvine, CA 92697, USA.; Chao Family Comprehensive Cancer Center, University of California Irvine, CA 92697, USA.
Jazyk:	angličtina
Zdroj:	Biomedical optics express [Biomed Opt Express] 2022 Oct 28; Vol. 13 (11), pp. 6100-6112. Date of Electronic Publication: 2022 Oct 28 (Print Publication: 2022).
DOI:	10.1364/BOE.469559
Abstrakt:	Image-guided small animal radiation research platforms allow more precise radiation treatment. Commercially available small animal X-ray irradiators are often equipped with a CT/cone-beam CT (CBCT) component for target guidance. Besides having poor soft-tissue contrast, CBCT unfortunately cannot provide molecular information due to its low sensitivity. Hence, there are extensive efforts to incorporate a molecular imaging component besides CBCT on these radiation therapy platforms. As an extension of these efforts, here we present a theranostic fluorescence tomography/CBCT-guided irradiator platform that provides both anatomical and molecular guidance, which can overcome the limitations of stand-alone CBCT. The performance of our hybrid system is validated using both tissue-like phantoms and mice ex vivo . Both studies show that fluorescence tomography can provide much more accurate quantitative results when CBCT-derived structural information is used to constrain the inverse problem. The error in the recovered fluorescence absorbance reduces nearly 10-fold for all cases, from approximately 60% down to 6%. This is very significant since high quantitative accuracy in molecular information is crucial to the correct assessment of the changes in tumor microenvironment related to radiation therapy. Competing Interests: The authors declare no conflicts of interest. (© 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.)
Databáze:	MEDLINE
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