Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study.

Autor:	Mohr NM; Emergency Medicine, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa, Iowa, USA nicholas-mohr@uiowa.edu.; Anesthesia, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA., Plumb ID; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Harland KK; Emergency Medicine, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa, Iowa, USA., Pilishvili T; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Fleming-Dutra KE; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Krishnadasan A; Olive View and Ronald Reagan-UCLA Medical Center Emergency Medicine, University of California - Los Angeles, Los Angeles, California, USA., Hoth KF; Internal Medicine, University of Iowa Carver College of Medicine, Iowa CIty, Iowa, USA., Saydah SH; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Mankoff Z; Emergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Haran JP; Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Briggs-Hagen M; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., León ES; Emergency Medicine, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa, Iowa, USA., Talan DA; Olive View and Ronald Reagan-UCLA Medical Center Emergency Medicine, University of California - Los Angeles, Los Angeles, California, USA.; Internal Medicine Division of Infectious Diseases, University of California - Los Angeles, Los Angeles, California, USA.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2023 Feb 02; Vol. 13 (2), pp. e063141. Date of Electronic Publication: 2023 Feb 02.
DOI:	10.1136/bmjopen-2022-063141
Abstrakt:	Objectives: Although COVID-19 vaccines offer protection against infection and severe disease, there is limited information on the effect of vaccination on prolonged symptoms following COVID-19. Our objective was to determine differences in prevalence of prolonged symptoms 6 weeks after onset of COVID-19 among healthcare personnel (HCP) by vaccination status, and to assess differences in timing of return to work. Design: Cohort analysis of HCP with COVID-19 enrolled in a multicentre vaccine effectiveness study. HCP with COVID-19 between December 2020 and August 2021 were followed up 6 weeks after illness onset. Setting: Health systems in 12 US states. Participants: HCP participating in a vaccine effectiveness study were eligible for inclusion if they had laboratory-confirmed symptomatic SARS-CoV-2 with mRNA vaccination (symptom onset ≥14 days after two doses) or no prior vaccination. Among 681 eligible participants, 419 (61%) completed a follow-up survey to assess symptoms reported 6 weeks after illness onset. Exposures: Two doses of a COVID-19 mRNA vaccine compared with no COVID-19 vaccine. Main Outcome Measures: Prevalence of symptoms 6 weeks after onset of COVID-19 illness and days to return to work. Results: Among 419 HCP with COVID-19, 298 (71%) reported one or more COVID-like symptoms 6 weeks after illness onset, with a lower prevalence among vaccinated participants compared with unvaccinated participants (60.6% vs 79.1%; adjusted risk ratio 0.70, 95% CI 0.58 to 0.84). Following their illness, vaccinated HCP returned to work a median 2.0 days (95% CI 1.0 to 3.0) sooner than unvaccinated HCP (adjusted HR 1.37, 95% CI 1.04 to 1.79). Conclusions: Receipt of two doses of a COVID-19 mRNA vaccine among HCP with COVID-19 illness was associated with decreased prevalence of COVID-like symptoms at 6 weeks and earlier return to work. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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