k-Carrageenan/sericin-based multiparticulate systems: A novel gastro-resistant polymer matrix for indomethacin delivery.

Autor: Vieira WT; University of Campinas, School of Chemical Engineering, Av. Albert Einstein, 500, Cidade Universitária 'Zeferino Vaz', Campinas, SP 13083-852, Brazil., da Silva MGC; University of Campinas, School of Chemical Engineering, Av. Albert Einstein, 500, Cidade Universitária 'Zeferino Vaz', Campinas, SP 13083-852, Brazil., de Oliveira Nascimento L; University of Campinas, School of Pharmaceutical Sciences, Rua Cândido Portinari, 200, Cidade Universitária 'Zeferino Vaz', Campinas, SP 13083-871, Brazil., Vieira MGA; University of Campinas, School of Chemical Engineering, Av. Albert Einstein, 500, Cidade Universitária 'Zeferino Vaz', Campinas, SP 13083-852, Brazil. Electronic address: melissag@unicamp.br.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2023 Mar 31; Vol. 232, pp. 123381. Date of Electronic Publication: 2023 Jan 31.
DOI: 10.1016/j.ijbiomac.2023.123381
Abstrakt: This study aimed to develop a natural and multiparticulate carrier of k-carrageenan (k-Car) and sericin (Ser) for encapsulation of indomethacin (IND) in order to minimize gastrointestinal effects caused by immediate-release. Increasing the amount of IND in the formulations subtly reduced the entrapment efficiency (EE) and drug loading (DL) due to matrix saturation. Sericin was essential to improve EE and DL when compared to pure k-Car (EE > 90 % and DL > 47 %) with suitable particle sizes (1.3461 ± 0.1891-1.7213 ± 0.1586 mm). The incorporation and integrity of IND in the particles were confirmed by analytical techniques of HPLC, XRD, FTIR, and SEM. Additionally, the k-Car/Ser matrix was pH-responsive with low IND release at pH 1.2 and extended-release at pH 6.8. The Weibull model had an adequate fit to the experimental data with R 2 aju 0.950.99 and AIC 82.4-24.9, with curves in parabolic profile (b < 1) and indicative of a controlled drug-release mechanism by diffusion. Besides, k-Car/Ser/IND and placebo were not cytotoxic (cell viability > 85 % at 150-600 μM) for the Caco-2 cell line. Therefore, the polymeric matrix is gastro-resistant, stable, and biocompatible to carry indomethacin and deliver it to the intestinal environment.
Competing Interests: Declaration of competing interest No conflicts of interest were declared by the authors of this study.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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