Pediatric case of septic arthritis due to Streptococcus pneumoniae serotype 19A.
| Autor: | Hristova PM; Medical University - Pleven, Department of Microbiology and Virology, Pleven, Bulgaria. Electronic address: preslavahristova@outlook.com., Hitkova HY; Medical University - Pleven, Department of Microbiology and Virology, Pleven, Bulgaria., Balgaranov NK; Medical University - Pleven, Department of Pediatrics, Pleven, Bulgaria., Gergova RТ; Medical University of Sofia, Department of Medical Microbiology, Sofia, Bulgaria., Alexandrova AS; Medical University of Sofia, Department of Medical Microbiology, Sofia, Bulgaria. |
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| Jazyk: | angličtina |
| Zdroj: | The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases [Braz J Infect Dis] 2023 Mar-Apr; Vol. 27 (2), pp. 102742. Date of Electronic Publication: 2023 Jan 31. |
| DOI: | 10.1016/j.bjid.2023.102742 |
| Abstrakt: | In recent years, the incidence of pediatric septic arthritis caused by Streptococcus pneumoniae has been quite low. The pneumococcal conjugate vaccine PCV10 is the available vaccine included in the Bulgarian national immunization program. PCV10 reduces the incidence of invasive diseases, but non-vaccinal serotypes like 19A, the etiologic agent of the case of septic arthritis reported herein in a 3-year-old boy. The synovial fluid was positive for S. pneumoniae. The patient was treated with vancomycin during hospitalization and trimethoprim/sulfamethoxazole was recommended for at-home treatment. The isolate was subjected to latex agglutination, antimicrobial susceptibility testing, PCR detection for macrolide-resistance genes, and MLST. The strain revealed ST695 and a genotype previously associated with vaccine serotype 4. The incidence of pneumococcal infections caused by capsule-switching events and non-PCV10 serotypes is expected to increase. Competing Interests: Conflicts of interest The authors declare no conflicts of interest. (Copyright © 2023 Sociedade Brasileira de Infectologia. Published by Elsevier España, S.L.U. All rights reserved.) |
| Databáze: | MEDLINE |
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