Fat Graft Retention: Adipose Tissue, Adipose-Derived Stem Cells, and Aging.
| Autor: | Trotzier C; From Advanced Research, L'Oréal Research and Innovation., Sequeira I; Institute of Dentistry, Centre for Oral Immunobiology and Regenerative Medicine, Queen Mary University of London., Auxenfans C; Banque de Tissus et de Cellules des Hospices Civils de Lyon, Edouard Herriot Hospital., Mojallal AA; Department of Plastic, Reconstructive and Aesthetic Surgery, La Croix Rousse Hospital, and Claude Bernard Lyon 1 University. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Plastic and reconstructive surgery [Plast Reconstr Surg] 2023 Mar 01; Vol. 151 (3), pp. 420e-431e. Date of Electronic Publication: 2022 Nov 22. |
| DOI: | 10.1097/PRS.0000000000009918 |
| Abstrakt: | Summary: Over the past 30 years, there has been a dramatic increase in the use of autologous fat grafting for soft-tissue augmentation and to improve facial skin quality. Several studies have highlighted the impact of aging on adipose tissue, leading to a decrease of adipose tissue volume and preadipocyte proliferation and increase of fibrosis. Recently, there has been a rising interest in adipose tissue components, including adipose-derived stem/stromal cells (ASCs) because of their regenerative potential, including inflammation, fibrosis, and vascularization modulation. Because of their differentiation potential and paracrine function, ASCs have been largely used for fat grafting procedures, as they are described to be a key component in fat graft survival. However, many parameters as surgical procedures or adipose tissue biology could change clinical outcomes. Variation on fat grafting methods have led to numerous inconsistent clinical outcomes. Donor-to-donor variation could also be imputed to ASCs, tissue inflammatory state, or tissue origin. In this review, the authors aim to analyze (1) the parameters involved in graft survival, and (2) the effect of aging on adipose tissue components, especially ASCs, that could lead to a decrease of skin regeneration and fat graft retention. Clinical Relevance Statement: This review aims to enlighten surgeons about known parameters that could play a role in fat graft survival. ASCs and their potential mechanism of action in regenerative medicine are more specifically described. (Copyright © 2022 by the American Society of Plastic Surgeons.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|