Limited Health Risks in Performing Drug Reconstitution and Handling Tasks in Pharmacies-Results of an Occupational Risk Assessment Study.
| Autor: | Crul M; From the Department of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Center, Amsterdam, the Netherlands (M.C.); Department of Hospital Pharmacy, Meander Medical Center, Amersfoort, the Netherlands (O.B.); Laboratory of the Dutch Pharmacists, Royal Dutch Pharmacists Association, the Hague, the Netherlands (S.N., O.S.); Netherlands Organization for Applied Scientific Research, Utrecht, the Netherlands (M.L.F., E.K.)., Breukels O, Ng S, Le Feber M, Kuijpers E, Smeets O |
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| Jazyk: | angličtina |
| Zdroj: | Journal of occupational and environmental medicine [J Occup Environ Med] 2023 Apr 01; Vol. 65 (4), pp. e204-e210. |
| DOI: | 10.1097/JOM.0000000000002781 |
| Abstrakt: | Objective: Some drugs need processing before they can be administered or dispensed. We measured airborne exposure of pharmacy staff to small particles when performing these tasks. Methods: Reconstitution of powdered drugs in vials; crushing, splitting, and counting of tablets; and opening of capsules, using different ventilation strategies, were investigated in five pharmacies after in a worst-case approach. Airborne particulate matter was determined for a range of particles sizes. Results: Mean particle concentrations ranged from not detectable to 1.03 μg/m 3 (<1 μm) and 589.7 μg/m 3 (<10 μm). Dust exhaust made tasks safer. Most hazardous was pouring out tablets from a bulk supply, and least hazardous was reconstitution of a powder for injection. Conclusions: Occupational exposure during routine handling of drugs can occur, but the risks vary greatly with the nature and duration of the tasks. Competing Interests: Conflict of Interest: None declared. (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Occupational and Environmental Medicine.) |
| Databáze: | MEDLINE |
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