Human bocavirus 1 epidemiology in children in relation to virus load and codetection.

Autor: Oldhoff E; Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden., Bennet R; Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden., Eriksson M; Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden., Allander T; Department of Clinical Microbiology, Karolinska university Hospital, Stockholm, Sweden.; Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Jazyk: angličtina
Zdroj: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2023 May; Vol. 112 (5), pp. 1049-1055. Date of Electronic Publication: 2023 Feb 15.
DOI: 10.1111/apa.16699
Abstrakt: Aim: Human bocavirus 1 (HBoV1) has been associated with respiratory tract infections in children. We aimed at retrospectively describing patient characteristics, seasonality, pre-existing medical conditions, codetections, clinical manifestations and complications of HBoV1 infection in relation to viral load in the child population in Stockholm, with the overarching aim of elucidating the clinical significance of HBoV1.
Methods: We included all hospitalised children 0-17 years testing positive for HBoV1 by real-time polymerase chain reaction on nasopharyngeal aspirates 1 July 2008-30 June 2019. Patients with HBoV1 single detection, high viral load expressed as an HBoV1-DNA cycle threshold (Ct) < 25, or both, were separately analysed. We retrieved information on pre-existing conditions and clinical course from the medical records.
Results: We found 768 episodes in 727 children, 496 (64.6%) male and 441 (60.7%) previously healthy. The median age was 17.6 months. Most (476/768, 62.0%) episodes occurred during December-March. HBoV1 was in 549 episodes (71.5%) codetected with other viruses. Ct < 25 was independently associated with young age, single detection of HBoV1 and presentation early in the epidemic season. We saw few differences in clinical manifestations between the subgroups.
Conclusion: Our findings are consistent with primary HBoV1 infection causing mild-to-severe respiratory tract manifestations in young children.
(© 2023 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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