Molecular Mimicry between Respiratory Syncytial Virus F Antigen and the Human Proteome.
| Autor: | Kanduc D; Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, Bari, Italy. |
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| Jazyk: | angličtina |
| Zdroj: | Global medical genetics [Glob Med Genet] 2023 Jan 30; Vol. 10 (1), pp. 19-21. Date of Electronic Publication: 2023 Jan 30 (Print Publication: 2023). |
| DOI: | 10.1055/s-0043-1761489 |
| Abstrakt: | This study examined respiratory syncytial virus (RSV) F glycoprotein (gp) antigen for molecular mimicry with the human proteome. It was found that the viral antigen presents an impressive number of pentapeptides (namely, 525 out of 570) in common with the human proteome, with viral sequences widely and repeatedly distributed among 3,762 human proteins implicated in crucial fundamental cellular functions. The data can have implications for anti-RSV vaccines. Indeed, the high level of molecular mimicry can lead to cross-reactivity and autoimmunity, and invites to follow safer vaccinal protocols based on pentapeptide sequences uniquely present in the viral antigen. Competing Interests: Conflicts of Interest None declared. (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ).) |
| Databáze: | MEDLINE |
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