Transferability of the PRS estimates for height and BMI obtained from the European ethnic groups to the Western Russian populations.

Autor:	Albert EA; National Medical Research Center for Endocrinology, Moscow, Russia.; Life Sciences Research Center, Moscow Institute of Physics and Technology, Dolgoprudniy, Russia., Kondratieva OA; Department of Information Systems, Ivannikov Institute for System Programming of the Russian Academy of Sciences, Moscow, Russia., Baranova EE; Evogen LLC, Moscow, Russia., Sagaydak OV; Evogen LLC, Moscow, Russia., Belenikin MS; Evogen LLC, Moscow, Russia., Zobkova GY; Evogen LLC, Moscow, Russia., Kuznetsova ES; Evogen LLC, Moscow, Russia., Deviatkin AA; National Medical Research Center for Endocrinology, Moscow, Russia.; Life Sciences Research Center, Moscow Institute of Physics and Technology, Dolgoprudniy, Russia., Zhurov AA; National Medical Research Center for Endocrinology, Moscow, Russia., Karpulevich EA; Department of Information Systems, Ivannikov Institute for System Programming of the Russian Academy of Sciences, Moscow, Russia., Volchkov PY; National Medical Research Center for Endocrinology, Moscow, Russia.; Life Sciences Research Center, Moscow Institute of Physics and Technology, Dolgoprudniy, Russia., Vorontsova MV; National Medical Research Center for Endocrinology, Moscow, Russia.
Jazyk:	angličtina
Zdroj:	Frontiers in genetics [Front Genet] 2023 Jan 16; Vol. 14, pp. 1086709. Date of Electronic Publication: 2023 Jan 16 (Print Publication: 2023).
DOI:	10.3389/fgene.2023.1086709
Abstrakt:	Genetic data plays an increasingly important role in modern medicine. Decrease in the cost of sequencing with subsequent increase in imputation accuracy, and the accumulation of large amounts of high-quality genetic data enable the creation of polygenic risk scores (PRSs) to perform genotype-phenotype associations. The accuracy of phenotype prediction primarily depends on the overall trait heritability, Genome-wide association studies cohort size, and the similarity of genetic background between the base and the target cohort. Here we utilized 8,664 high coverage genomic samples collected across Russia by "Evogen", a Russian biomedical company, to evaluate the predictive power of PRSs based on summary statistics established on cohorts of European ancestry for basic phenotypic traits, namely height and BMI. We have demonstrated that the PRSs calculated for selected traits in three distinct Russian populations, recapitulate the predictive power from the original studies. This is evidence that GWAS summary statistics calculated on cohorts of European ancestry are transferable onto at least some ethnic groups in Russia. Competing Interests: BEE, SOV, BMS, GYZ, and KES were employed by the company LCC Evogen. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Albert, Kondratieva, Baranova, Sagaydak, Belenikin, Zobkova, Kuznetsova, Deviatkin, Zhurov, Karpulevich, Volchkov and Vorontsova.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu