High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight.

Autor: Korgan AC; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA., Oliveira-Abreu K; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.; Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, CE, Brazil., Wei W; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.; Georgia State University, Atlanta, GA, USA., Martin SLA; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA., Bridges ZJD; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA., Leal-Cardoso JH; Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, CE, Brazil., Kaczorowski CC; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.; Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, USA.; Neuroscience Program, Graduate School of Biomedical Science, Tufts University School of Medicine, Boston, MA, USA., O'Connell KMS; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA. kristen.oconnell@jax.org.; Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, USA. kristen.oconnell@jax.org.; Neuroscience Program, Graduate School of Biomedical Science, Tufts University School of Medicine, Boston, MA, USA. kristen.oconnell@jax.org.
Jazyk: angličtina
Zdroj: International journal of obesity (2005) [Int J Obes (Lond)] 2023 Mar; Vol. 47 (3), pp. 224-235. Date of Electronic Publication: 2023 Feb 01.
DOI: 10.1038/s41366-023-01265-w
Abstrakt: Background/objective: As the obesity epidemic continues, the understanding of macronutrient influence on central nervous system function is critical for understanding diet-induced obesity and potential therapeutics, particularly in light of the increased sugar content in processed foods. Previous research showed mixed effects of sucrose feeding on body weight gain but has yet to reveal insight into the impact of sucrose on hypothalamic functioning. Here, we explore the impact of liquid sucrose feeding for 12 weeks on body weight, body composition, caloric intake, and hypothalamic AgRP neuronal function and synaptic plasticity.
Methods: Patch-clamp electrophysiology of hypothalamic AgRP neurons, metabolic phenotyping and food intake were performed on C57BL/6J mice.
Results: While mice given sugar-sweetened water do not gain significant weight, they do show subtle differences in body composition and caloric intake. When given sugar-sweetened water, mice show similar alterations to AgRP neuronal excitability as in high-fat diet obese models. Increased sugar consumption also primes mice for increased caloric intake and weight gain when given access to a HFD.
Conclusions: Our results show that elevated sucrose consumption increased activity of AgRP neurons and altered synaptic excitability. This may contribute to obesity in mice and humans with access to more palatable (HFD) diets.
(© 2023. The Author(s).)
Databáze: MEDLINE
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