Age at cancer diagnosis by breed, weight, sex, and cancer type in a cohort of more than 3,000 dogs: Determining the optimal age to initiate cancer screening in canine patients.

Autor: Rafalko JM; Medical & Clinical Affairs, PetDx, La Jolla, California, United States of America., Kruglyak KM; Information Technology & Bioinformatics, PetDx, La Jolla, California, United States of America., McCleary-Wheeler AL; Research & Development, PetDx, La Jolla, California, United States of America., Goyal V; Information Technology & Bioinformatics, PetDx, La Jolla, California, United States of America., Phelps-Dunn A; Medical & Clinical Affairs, PetDx, La Jolla, California, United States of America., Wong LK; Medical & Clinical Affairs, PetDx, La Jolla, California, United States of America., Warren CD; Medical & Clinical Affairs, PetDx, La Jolla, California, United States of America., Brandstetter G; Medical & Clinical Affairs, PetDx, La Jolla, California, United States of America., Rosentel MC; Medical & Clinical Affairs, PetDx, La Jolla, California, United States of America., DiMarzio L; Medical & Clinical Affairs, PetDx, La Jolla, California, United States of America., McLennan LM; Clinical Studies, PetDx, La Jolla, California, United States of America., O'Kell AL; Medical & Clinical Affairs, PetDx, La Jolla, California, United States of America., Cohen TA; Medical & Clinical Affairs, PetDx, La Jolla, California, United States of America., Grosu DS; Chief Executive Officer, PetDx, La Jolla, California, United States of America., Chibuk J; Medical & Clinical Affairs, PetDx, La Jolla, California, United States of America., Tsui DWY; Research & Development, PetDx, La Jolla, California, United States of America., Chorny I; Information Technology & Bioinformatics, PetDx, La Jolla, California, United States of America., Flory A; Medical & Clinical Affairs, PetDx, La Jolla, California, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Feb 01; Vol. 18 (2), pp. e0280795. Date of Electronic Publication: 2023 Feb 01 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0280795
Abstrakt: The goal of cancer screening is to detect disease at an early stage when treatment may be more effective. Cancer screening in dogs has relied upon annual physical examinations and routine laboratory tests, which are largely inadequate for detecting preclinical disease. With the introduction of non-invasive liquid biopsy cancer detection methods, the discussion is shifting from how to screen dogs for cancer to when to screen dogs for cancer. To address this question, we analyzed data from 3,452 cancer-diagnosed dogs to determine the age at which dogs of certain breeds and weights are typically diagnosed with cancer. In our study population, the median age at cancer diagnosis was 8.8 years, with males diagnosed at younger ages than females, and neutered dogs diagnosed at significantly later ages than intact dogs. Overall, weight was inversely correlated with age at cancer diagnosis, and purebred dogs were diagnosed at significantly younger ages than mixed-breed dogs. For breeds represented by ≥10 dogs, a breed-based median age at diagnosis was calculated. A weight-based linear regression model was developed to predict the median age at diagnosis for breeds represented by ≤10 dogs and for mixed-breed dogs. Our findings, combined with findings from previous studies which established a long duration of the preclinical phase of cancer development in dogs, suggest that it might be reasonable to consider annual cancer screening starting 2 years prior to the median age at cancer diagnosis for dogs of similar breed or weight. This logic would support a general recommendation to start cancer screening for all dogs at the age of 7, and as early as age 4 for breeds with a lower median age at cancer diagnosis, in order to increase the likelihood of early detection and treatment.
Competing Interests: All authors are employed by and hold vested or unvested equity in PetDx. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
(Copyright: © 2023 Rafalko et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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