Single-Dose Antibiotic Prophylaxis with Ertapenem Increases Compliance with Recommendations for Surgical Antibiotic Prophylaxis in Elective Colorectal Surgery: A Retrospective, Single-Center Analysis.

Autor:	Field AM; Department of Pharmacy, State University of New York Upstate University Hospital, Syracuse, New York, USA.; Department of Pharmacy, University of Virginia Health, Charlottesville, Virginia, USA., Seabury RW; Department of Pharmacy, State University of New York Upstate University Hospital, Syracuse, New York, USA.; Department of Medicine, State University of New York Upstate University Hospital, Syracuse, New York, USA., Kufel WD; Department of Pharmacy, State University of New York Upstate University Hospital, Syracuse, New York, USA.; Department of Medicine, State University of New York Upstate University Hospital, Syracuse, New York, USA.; Binghamton University School of Pharmacy and Pharmaceutical Sciences, Binghamton, New York, USA., Darko W; Department of Pharmacy, State University of New York Upstate University Hospital, Syracuse, New York, USA.; Department of Medicine, State University of New York Upstate University Hospital, Syracuse, New York, USA., Miller CD; Department of Pharmacy, State University of New York Upstate University Hospital, Syracuse, New York, USA.; Department of Medicine, State University of New York Upstate University Hospital, Syracuse, New York, USA., Mastro KA; Department of Pharmacy, State University of New York Upstate University Hospital, Syracuse, New York, USA.; Binghamton University School of Pharmacy and Pharmaceutical Sciences, Binghamton, New York, USA., Steele JM; Department of Pharmacy, State University of New York Upstate University Hospital, Syracuse, New York, USA.; Department of Medicine, State University of New York Upstate University Hospital, Syracuse, New York, USA.
Jazyk:	angličtina
Zdroj:	Surgical infections [Surg Infect (Larchmt)] 2023 Mar; Vol. 24 (2), pp. 177-182. Date of Electronic Publication: 2023 Jan 31.
DOI:	10.1089/sur.2022.253
Abstrakt:	Background: Compliance with guideline recommendations for surgical antibiotic prophylaxis (SAP) in colorectal surgery, particularly redosing, has been suboptimal at many institutions including ours. This study aimed to evaluate if single-dose antibiotic prophylaxis with ertapenem improves compliance with guideline recommendations for SAP versus multiple-dose antibiotic prophylaxis in elective colorectal surgery. Methods: A retrospective, cohort study of the use of ertapenem compared with standard of care antibiotic agents was performed in adult patients undergoing elective colorectal surgery at an academic medical center between January 2020 and February 2022. The primary outcome was compliance with guideline-recommended SAP for colorectal surgery. The secondary outcome was surgical site infections (SSIs) within 30 days after surgery. Results: A total of 135 patients were included in this study. Fifty-eight patients received single-dose antibiotic prophylaxis with ertapenem and 77 patients received multiple-dose antibiotic prophylaxis. Cefazolin plus metronidazole was the most common multiple-dose regimen (65 of 77). Single-dose antibiotic prophylaxis with ertapenem increased overall SAP compliance (96.6% vs. 64.9%; p < 0.001) as well as compliance with antibiotic administration within the recommended time period before incision (96.6% vs. 84.4%; p = 0.022), compliance with intra-operative antibiotic redosing when warranted (100% vs. 83.1%; p < 0.001), and compliance with guideline-recommended dosing (100% vs. 92.2%; p = 0.037). Surgical site infection rates were not statistically different between the groups (12.1% vs. 19.4%; p = 0.248). Conclusions: Single-dose antibiotic prophylaxis with ertapenem increased compliance with guideline-recommended SAP for elective colorectal surgeries. No statistically significant difference was observed in SSI rates regardless of the antibiotic regimen used.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu