| Autor: |
Mai NT; Faculty of Basic Sciences, University of Transport and Communications, Hanoi, Vietnam., Anh BTM; Faculty of Basic Sciences, University of Transport and Communications, Hanoi, Vietnam., Xuan VT; Faculty of Basic Sciences, University of Transport and Communications, Hanoi, Vietnam., Lan HTT; Faculty of Basic Sciences, University of Transport and Communications, Hanoi, Vietnam., Yen DTH; Department of Structural Research, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam., Tai BH; Department of Structural Research, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam.; Faculty of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam., Nhiem NX; Department of Structural Research, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam.; Faculty of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam., Van Kiem P; Department of Structural Research, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam.; Faculty of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam. |
| Abstrakt: |
Phytochemical study on the roots of Achyranthes bidentata Blume led to the isolation of sixteen compounds including three new ones ( 1-3 ). Their chemical structures were determined as oleanolic acid 28- O - β -D-glucopyranoside-3- O -[ β -D-glucopyranosyl-(1→3)- β -D-galactopyranoside) ( 1 ), methyl (8 Z ,11 Z )-5,6,7-trihydroxytetradeca-8,11-dienoate ( 2 ), methyl (6 E ,11 Z )-5,8,9-trihydroxytetradeca-6,11-dienoate ( 3 ), fulgidic acid ( 4 ), (9 E ,11 E )-13-oxooctadeca-9,11-dienoic acid ( 5 ), (9 Z ,11 E ,15 Z )-13-hydroxyoctadeca-9,11,15-trienoic acid ( 6 ), oleanolic acid 28- O - β -D-glucopyranoside-3- O - α -L-rhamnopyranosyl-(1→4)- β -D-glucuronopyranoside ( 7 ), oleanolic acid 28- O - β -D-glucopyranoside-3- O - β -D - glucopyranosyl-(1→2)-[ α -L-rhamnopyranosyl-(1→3)]- β -D-glucuronopyranoside ( 8 ), oleanolic acid 3- O - β -D - glucopyranosyl-(1→2)-[ α -L-rhamnopyranosyl-(1→3)]- β -D-glucuronopyranoside ( 9 ), oleanolic acid 3- O - α -L-rhamnopyranosyl-(1→3)- β -D-glucuronopyranoside ( 10 ), blumenol C glucoside ( 11 ), citroside A ( 12 ), 6 S ,9 S -roseoside ( 13 ), ginsenoside Rg1 ( 14 ), 20-hydroxyecdysone ( 15 ), and benzyl α -L-rhamnopyranosyl-(1→6)]- β -D-glucopyranoside ( 16 ) by spectroscopic analysis. Compounds 1 , 7 and 11-16 inhibited NO production in LPS-activated RAW264.7 cells with IC 50 values in the range from 28.03 to 54.23 µM (positive control, L-NMMA: IC 50 = 35.52 µM). Compounds 14 and 15 showed anti α -glucosidase activity with IC 50 values of 176.24 and 156.92 µM, respectively, compared with the positive control, acarbose, IC 50 = 160.99 μM. |
