Absence of VGLUT3 Expression Leads to Impaired Fear Memory in Mice.

Autor:	de Almeida C; Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), Paris 75005, France., Chabbah N; Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), Paris 75005, France., Eyraud C; Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), Paris 75005, France., Fasano C; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal QC H4H 1R3, Quebec, Canada., Bernard V; Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), Paris 75005, France., Pietrancosta N; Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), Paris 75005, France., Fabre V; Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), Paris 75005, France., El Mestikawy S; Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), Paris 75005, France.; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal QC H4H 1R3, Quebec, Canada., Daumas S; Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), Paris 75005, France stephanie.daumas@sorbonne-universite.fr.
Jazyk:	angličtina
Zdroj:	ENeuro [eNeuro] 2023 Feb 23; Vol. 10 (2). Date of Electronic Publication: 2023 Feb 23 (Print Publication: 2023).
DOI:	10.1523/ENEURO.0304-22.2023
Abstrakt:	Fear is an emotional mechanism that helps to cope with potential hazards. However, when fear is generalized, it becomes maladaptive and represents a core symptom of posttraumatic stress disorder (PTSD). Converging lines of research show that dysfunction of glutamatergic neurotransmission is a cardinal feature of trauma and stress related disorders such as PTSD. However, the involvement of glutamatergic co-transmission in fear is less well understood. Glutamate is accumulated into synaptic vesicles by vesicular glutamate transporters (VGLUTs). The atypical subtype, VGLUT3, is responsible for the co-transmission of glutamate with acetylcholine, serotonin, or GABA. To understand the involvement of VGLUT3-dependent co-transmission in aversive memories, we used a Pavlovian fear conditioning paradigm in VGLUT3 -/- mice. Our results revealed a higher contextual fear memory in these mice, despite a facilitation of extinction. In addition, the absence of VGLUT3 leads to fear generalization, probably because of a pattern separation deficit. Our study suggests that the VGLUT3 network plays a crucial role in regulating emotional memories. Hence, VGLUT3 is a key player in the processing of aversive memories and therefore a potential therapeutic target in stress-related disorders. Competing Interests: The authors declare no competing financial interests. (Copyright © 2023 de Almeida et al.)
Databáze:	MEDLINE
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