Myeloid-like B cells boost emergency myelopoiesis through IL-10 production during infection.

Autor:	Kanayama M; Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University , Tokyo, Japan., Izumi Y; Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University , Tokyo, Japan., Akiyama M; Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University , Tokyo, Japan., Hayashi T; Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University , Tokyo, Japan., Atarashi K; Department of Microbiology and Immunology, Keio University School of Medicine , Tokyo, Japan., Roers A; Institute for Immunology, Heidelberg University Hospital , Heidelberg, Germany., Sato T; Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University , Tokyo, Japan., Ohteki T; Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University , Tokyo, Japan.
Jazyk:	angličtina
Zdroj:	The Journal of experimental medicine [J Exp Med] 2023 Apr 03; Vol. 220 (4). Date of Electronic Publication: 2023 Jan 31.
DOI:	10.1084/jem.20221221
Abstrakt:	Emergency myelopoiesis (EM) is a hematopoietic response against systemic infections that quickly supplies innate immune cells. As lymphopoiesis is strongly suppressed during EM, the role of lymphocytes in that process has not received much attention. Here, we found that myeloid-like B cells (M-B cells), which express myeloid markers, emerge in the bone marrow (BM) after the induction of EM. M-B cells were mainly derived from pre-B cells and preferentially expressed IL-10, which directly stimulates hematopoietic progenitors to enhance their survival and myeloid-biased differentiation. Indeed, lacking IL-10 in B cells, blocking IL-10 in the BM with a neutralizing antibody, and deleting the IL-10 receptor in hematopoietic progenitors significantly suppressed EM, which failed to clear microbes in a cecal ligation and puncture model. Thus, a distinct B cell subset generated during infection plays a pivotal role in boosting EM, which suggests the on-demand reinforcement of EM by adaptive immune cells. (© 2023 Kanayama et al.)
Databáze:	MEDLINE
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