Neurodevelopmental disorders (NDD) without boundaries: research and interventions beyond classifications.

Autor: Louveau C; GHU-Paris Psychiatrie et Neurosciences, Paris, France., Ellul P; Excellence Centre for Autism and Neuro-Developmental Disorders, Child and Adolescent Psychiatry Department, Robert Debré Hospital, Paris Cité University, Paris, France.; Immunology, Immunopathology, Immunotherapy, INSERM U959, Sorbonne University, Paris, France., Iftimovici A; GHU-Paris Psychiatrie et Neurosciences, Paris, France.; Université de Paris, INSERM U1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France., Dubreucq J; Child and Adolescent Psychiatry Department, Saint-Etienne University Hospital and CNRS UMR 5229, Institute of Cognitive Neuroscience Marc Jeannerod, University Lyon 1, Bron, France., Laidi C; Child Mind Institute, New York, USA., Leyrolle Q; Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, Bordeaux, France., Purper-Ouakil D; CHU Montpellier-Saint Eloi Hospital, University of Montpellier, Unit of Child and Adolescent Psychiatry (MPEA1), Montpellier, France.; Center for Research in Epidemiology and Population Health (CESP), INSERM U 1018, Paris-Saclay University, Villejuif, France., Jacquemont S; Department of Pediatrics, Sainte Justine Hospital Research Center, University of Montreal, Montreal, QC, H4A3J1, Canada., Lyonnet S; INSERM-UMR1163, Université Paris Cité, Institut Imagine, Paris, France., Barthélémy C; Faculty of Medicine, University of Tours, Tours, France.; Autism and NDD GIS (GIS Autisme et Troubles du Neurodéveloppement), Paris, France., Krebs MO; GHU-Paris Psychiatrie et Neurosciences, Paris, France.; Université de Paris, INSERM U1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.; Autism and NDD GIS (GIS Autisme et Troubles du Neurodéveloppement), Paris, France., Bai J; Université de Paris, INSERM U1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France., Olivier P; Autism and NDD GIS (GIS Autisme et Troubles du Neurodéveloppement), Paris, France. paul.olivier2@inserm.fr., Chaumette B; GHU-Paris Psychiatrie et Neurosciences, Paris, France.; Université de Paris, INSERM U1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.; Autism and NDD GIS (GIS Autisme et Troubles du Neurodéveloppement), Paris, France.; Department of Psychiatry, McGill University, Montreal, Canada.
Jazyk: angličtina
Zdroj: Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2023 Mar; Vol. 130 (3), pp. 473-479.
DOI: 10.1007/s00702-023-02586-w
Abstrakt: On June 2022, the 2nd Webinar "Neurodevelopmental Disorders (NDD) without boundaries took place at the Imagine Institute in Paris and was broadcasted live and in replay. The aim of this webinar is to address NDD in a dimensional rather than in a categorical approach. Several speakers were invited to present their researches on the subject. Classifications in NDD were discussed: irritability in NDD, involvement of the immune system in neurodevelopment, nutrition and gut microbiota modulate brain inflammation and neurodevelopment, co-occurring conditions in autistic adolescents and adults without intellectual disability. Classifications in psychiatric disorders were asked: mapping the effect of genes on cognition and autism risk, epigenetics and symptomatic trajectory in neurodevelopmental disorders, the autism-schizophrenia continuum in two examples: minor neurological signs and EEG microstates, the cerebellum in schizophrenia and autism: from imaging to intervention perspectives. Both genetic and environmental factors, along with clinical and imaging features, argue toward a continnum between NDD but also with adult psychiatric presentations. This new paradigm could modify the therapeutic strategy, with the development of large-spectrum treatments or new psychotherapies addressing co-occuring symptoms. The complexity and the heterogeneity of NDD apply well to the next scientific and political challenges: developing international convergence to push back the frontiers of our knowledge. This article is a summary of the 2nd webinar "Neurodevelopmental Disorders (NDD) without boundaries: research and interventions beyond classifications" sponsored by the French National Academy of Medicine, the autism and neurodevelopmental disorders scientific interest group (GIS), the International Research Network Dev-O-Psy and the French Institute of Psychiatry (GDR3557). Oral presentations are available as a replay on the following website (in French): https://autisme-neurodev.org/evenements/2022/04/12/tnd-sans-frontieres-la-recherche-et-les-interventions-au-dela-des-classifications/ .
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)
Databáze: MEDLINE
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