Versatile RNA: overlooked gems of the transcriptome.

Autor: Erdem M; Department of Biological Sciences, Middle East Technical University, Ankara, Turkey., Cicek M; Department of Biology, Kamil Ozdag Faculty of Science, Karamanoglu Mehmetbey University, Karaman, Turkey., Erson-Bensan AE; Department of Biological Sciences, Middle East Technical University, Ankara, Turkey.
Jazyk: angličtina
Zdroj: The FEBS journal [FEBS J] 2023 Oct; Vol. 290 (20), pp. 4843-4851. Date of Electronic Publication: 2023 Feb 09.
DOI: 10.1111/febs.16742
Abstrakt: The critical role of RNA, its use and targetability concerning different aspects of human health are gaining more attention because our understanding of the versatility of RNA has dramatically evolved over the last decades. We now appreciate that RNA is far more critical than a messenger molecule and possesses many complicated functions. As a multifunctional molecule with its sequence, flexible structures and enzymatic abilities, RNA is genuinely powerful. Mammalian transcriptomes consist of a dynamically regulated plethora of coding and noncoding RNA types. However, some aspects of RNA metabolism remain to be explored. In this Viewpoint, we focus on the transcriptome's unconventional and possibly overlooked aspects to emphasize the importance of RNA in mammalian systems.
(© 2023 Federation of European Biochemical Societies.)
Databáze: MEDLINE
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