Chlorogenic acid attenuates cisplatin-induced ovarian injury in rats.
| Autor: | Ayazoglu Demir E; Department of Chemistry and Chemical Processing Technologies, Macka Vocational School, Karadeniz Technical University, Trabzon, Turkey., Mentese A; Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey., Livaoglu A; Department of Pathology, Kanuni Training and Research Hospital, University of Health Sciences, Trabzon, Turkey., Turkmen Alemdar N; Department of Medical Biochemistry, Graduate School of Health Sciences, Karadeniz Technical University, Trabzon, Turkey.; Department of Medical Services and Techniques, Vocational School of Health Services, Recep Tayyip Erdogan University, Rize, Turkey., Aliyazicioglu Y; Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey., Demir S; Department of Nutrition and Dietetics, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Drug and chemical toxicology [Drug Chem Toxicol] 2024 Mar; Vol. 47 (2), pp. 213-217. Date of Electronic Publication: 2023 Jan 31. |
| DOI: | 10.1080/01480545.2023.2172181 |
| Abstrakt: | The aim of this study was to determine the possible therapeutic effect of chlorogenic acid (CGA) on cisplatin (CDDP)-induced ovarian damage in rats. Rats were first exposed to CDDP (5 mg/kg) and then treated CGA (1.5 and 3 mg/kg) for three days. Oxidative stress (OS), inflammation and apoptosis markers were determined using spectrophotometric methods. Ovarian tissues were also evaluated histologically. The levels of OS, inflammation and apoptosis biomarkers increased by CDDP administration ( p < 0.05). Treatments with CGA significantly alleviated these markers dose-dependently ( p < 0.05). These data reveal that CGA may exert an ovoprotective effect by reducing pro-inflammatory mediators and enhancing antioxidant status in ovarian tissue. |
| Databáze: | MEDLINE |
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