Efficacy of a 0.5% Propolis -0.9% Pomegranate Buccal Spray Treatment Compared with 2% Miconazole Gel for Denture Stomatitis Treatment in Elderly Patients: a Randomized Clinical Trial.

Autor:	Maria Parro Y; Tropical Medicine Postgraduate Program, School of Medicine, University of Brasília, Brasília, DF, Brazil., de Mendonça Guimarães D; Dental Student, Dept. of Dentistry, School of Health Sciences, University of Brasília, Brasília, DF, Brazil., Sampaio Muller H; Molecular Biology Postgraduate Program, Institute of Biological Sciences, University of Brasília, Brasília, DF, Brazil., Barbosa Coelho E; Dept. of Internal Medicine, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil., Aparecida Berretta A; Apis Flora Industrial e Comercial Ltda, Ribeirão Preto, SP, Brazil., Aparecida de Lima J; Apis Flora Industrial e Comercial Ltda, Ribeirão Preto, SP, Brazil., De Jong D; Genetics Department, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil., de Paulo Martins VT; Institute of Biological Sciences, University of Brasília, Brasília, DF, Brazil., Negrini Lia E; Dept. of Dentistry, School of Health Sciences, DF, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of dentistry (Shiraz, Iran) [J Dent (Shiraz)] 2022 Dec; Vol. 23 (4), pp. 472-479.
DOI:	10.30476/DENTJODS.2021.91479.1588
Abstrakt:	Statement of the Problem: Natural products have attracted interest as an alternative to synthetic medi-cations for the treatment of oral diseases due to their efficacy and safety. Propolis and pomegranate extracts have both demonstrated efficacy for the treatment of denture stomatitis. However, use of the two compounds together has not been tested for this purpose. Purpose: A comparison was made of the efficacy of a commercially available propolis-pomegranate buccal spray formulation for the treatment of denture stomatitis, compared with miconazole gel, based on stomatitis lesions and Candida spp. concentrations in mouth rinses. Materials and Method: This was an experimental study, characterized as an open-label, parallel two-armed, non-inferiority randomized clinical trial. Forty elderly adults aged < 60 years with denture stoma-titis were randomly allocated to two groups. The patients applied a buccal spray containing 0.5% propo-lis and 0.9% pomegranate extracts or 2% miconazole gel, a standard treatment recommended in Brazil, to the inner surface of their dentures three times a day for 14 days. They were examined at days 1, 7, 14 and stomatitis lesions were categorized according to Newton's score. Mouth rinses were made with saline solution at days 1 and 14 and then assessed for Candida spp. Results: Both treatments reduced the Newton's score, with clinical cure rates of 75 and 40% for the miconazole and propolis-pomegranate groups, respectively. The Candida concentrations in the mouth rinse decreased significantly only in the miconazole group. Conclusion: The propolis-pomegranate spray was less effective than the miconazole treatment. Howev-er, clinical improvement was also observed in patients treated with the propolis-pomegranate buccal spray. Competing Interests: Andresa Aparecida Berretta and Jessica Aparecida de Lima are employed at Apis Flora Industrial e Comercial Ltda., Ribeirão Preto, SP, Brazil. The other authors confirm that they have no known conflicts of interest associated with this publication. (Copyright: © Journal of Dentistry.)
Databáze:	MEDLINE
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