Association of circadian rhythm with mild cognitive impairment among male pneumoconiosis workers in Hong Kong: a cross-sectional study.

Autor: Huang B; JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China., Liao G; JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China., Lee PMY; JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China., Chan CK; Pneumoconiosis Clinic, Tuberculosis and Chest Service, Department of Health, Hong Kong SAR, China., Tai LB; Pneumoconiosis Clinic, Tuberculosis and Chest Service, Department of Health, Hong Kong SAR, China., Tsang CYJ; Pneumoconiosis Mutual Aid Association, Hong Kong SAR, China., Leung CC; Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong SAR, China., Tse LA; JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China. shelly@cuhk.edu.hk.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Jan 30; Vol. 13 (1), pp. 1650. Date of Electronic Publication: 2023 Jan 30.
DOI: 10.1038/s41598-023-28832-5
Abstrakt: Weakened circadian activity rhythms (CARs) were associated with mild cognitive impairment (MCI) in the general population. However, it remains unclear among pneumoconiosis patients. We aimed to address this knowledge gap. This cross-sectional study comprised 186 male pneumoconiosis patients (71.3 ± 7.8 years) and 208 healthy community men. Actigraphy was used to determine CARs parameters (percent rhythm, amplitude, MESOR, and acrophase). Values below the corresponding medians of the CARs parameters represented weakened CARs. The Cantonese version of Mini-Mental State Examination (CMMSE) was used to assess cognitive function, MCI, and the composite outcome of MCI plus cognitive impairment. Compared with the community referents, pneumoconiosis patients had worse cognition and dampened CARs. Compared with the community referents or pneumoconiosis patients with robust circadian rhythm, pneumoconiosis patients with weakened circadian rhythm were consistently associated with increased risk of MCI and the composite outcome. However, significant association was only observed between MESOR and the composite outcome (adjusted OR = 1.99, 95%: 1.04-3.81). A delayed phase of CARs was insignificantly associated with MCI and the composite outcome. Our findings showed that weakened CARs were associated with worse cognitive function among male pneumoconiosis workers. Intervention in improving CARs may mitigate cognitive deterioration in male pneumoconiosis workers.
(© 2023. The Author(s).)
Databáze: MEDLINE
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