Gaining Wings to FLY: Using Drosophila Oogenesis as an Entry Point for Citizen Scientists in Laboratory Research.

Autor:	Ruiz-Whalen DM; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA. Dara.Ruiz-Whalen@ecloseinstitute.org.; eCLOSE Institute, Huntingdon Valley, PA, USA. Dara.Ruiz-Whalen@ecloseinstitute.org., Aichele CP; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA.; eCLOSE Institute, Huntingdon Valley, PA, USA., Dyson ER; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA.; eCLOSE Institute, Huntingdon Valley, PA, USA., Gallen KC; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA.; eCLOSE Institute, Huntingdon Valley, PA, USA., Stark JV; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Saunders JA; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Simonet JC; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA.; Arcadia University, Glenside, PA, USA., Ventresca EM; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA.; Albright College, Reading, PA, USA., Fuentes IM; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Marmol N; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Moise E; eCLOSE Institute, Huntingdon Valley, PA, USA., Neubert BC; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Riggs DJ; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA.; eCLOSE Institute, Huntingdon Valley, PA, USA., Self AM; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Alexander JI; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA.; eCLOSE Institute, Huntingdon Valley, PA, USA., Boamah E; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Browne AJ; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Correa I; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA.; eCLOSE Institute, Huntingdon Valley, PA, USA., Foster MJ; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Harrington N; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Holiday TJ; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Henry RA; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA.; Wilkes University, Wilkes-Barre, PA, USA., Lee EH; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Longo SM; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Lorenz LD; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Martinez E; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Nikonova A; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Radu M; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Smith SC; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Steele LA; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Strochlic TI; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA.; Department of Biochemistry and Molecular Biology, Drexel University, Philadelphia, PA, USA., Archer NF; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Aykit YJ; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Bolotsky AJ; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Boyle M; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Criollo J; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Eldor O; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Cruz G; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Fortuona VN; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA.; eCLOSE Institute, Huntingdon Valley, PA, USA., Gounder SD; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Greenwood N; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Ji KW; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Johnson A; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA.; eCLOSE Institute, Huntingdon Valley, PA, USA., Lara S; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Montanez B; eCLOSE Institute, Huntingdon Valley, PA, USA., Saurman M; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Singh T; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Smith DR; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Stapf CA; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Tondapu T; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Tsiobikas C; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Habas R; Department of Biology, Temple University, Philadelphia, PA, USA., O'Reilly AM; Immersion Science Program, Fox Chase Cancer Center, Philadelphia, PA, USA. Alana.OReilly@fccc.edu.; eCLOSE Institute, Huntingdon Valley, PA, USA. Alana.OReilly@fccc.edu.
Jazyk:	angličtina
Zdroj:	Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2023; Vol. 2626, pp. 399-444.
DOI:	10.1007/978-1-0716-2970-3_22
Abstrakt:	Citizen science is a productive approach to include non-scientists in research efforts that impact particular issues or communities. In most cases, scientists at advanced career stages design high-quality, exciting projects that enable citizen contribution, a crowdsourcing process that drives discovery forward and engages communities. The challenges of having citizens design their own research with no or limited training and providing access to laboratory tools, reagents, and supplies have limited citizen science efforts. This leaves the incredible life experiences and immersion of citizens in communities that experience health disparities out of the research equation, thus hampering efforts to address community health needs with a full picture of the challenges that must be addressed. Here, we present a robust and reproducible approach that engages participants from Grade 5 through adult in research focused on defining how diet impacts disease signaling. We leverage the powerful genetics, cell biology, and biochemistry of Drosophila oogenesis to define how nutrients impact phenotypes associated with genetic mutants that are implicated in cancer and diabetes. Participants lead the project design and execution, flipping the top-down hierarchy of the prevailing scientific culture to co-create research projects and infuse the research with cultural and community relevance. (© 2023. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze:	MEDLINE
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