Drug-drug interactions of Integrase Strand Transfer Inhibitors among older people living with HIV: Interazioni farmacologiche degli inibitori delle integrase tra le persone anziane che vivono con HIV.

Autor:	Wang H; Department of Pharmacy Practice, Texas Southern University College of Pharmacy and Health Sciences, Houston, TX, USA.; Department of Pharmacy, Houston Methodist Hospital, Houston, TX, USA., Ikwuagwu JO; Department of Pharmacy, Houston Methodist Hospital, Houston, TX, USA., Tran V; Department of Pharmacy Practice, Texas Southern University College of Pharmacy and Health Sciences, Houston, TX, USA., Tran NAK; Department of Pharmacy Practice, Texas Southern University College of Pharmacy and Health Sciences, Houston, TX, USA.
Jazyk:	angličtina
Zdroj:	Journal of HIV and ageing [J HIV Ageing] 2022 Jun; Vol. 7 (2), pp. 29-36.
DOI:	10.19198/jha31533
Abstrakt:	The advancement of Human Immunodeficiency Virus (HIV) treatment improves the life expectancy of HIV-positive individuals. People living with HIV have more polypharmacy and drug-drug interactions than those without HIV. Integrase strand transfer inhibitors (INSTIs) are the newest class commonly used for HIV treatment. There are five INSTIs currently approved by the Food and Drug Administration, including raltegravir, elvitegravir, dolutegravir, bictegravir, and cabotegravir. INSTIs class contributes to better safety and efficacy profile, making them the preferred or recommended antiretroviral regimens in HIV treatment guidelines worldwide. Despite the shared mechanism of action, INSTIs differ in pharmacokinetics, contributing to different drug-drug interactions. This review summarized the potential drug interactions of INSTIs and the management of the drug interactions in clinical practice. Competing Interests: Conflict of Interest Disclosures This manuscript is not under consideration by any other journal, and it does not duplicate publication or submission elsewhere or any part of the work. The manuscript has been read, reviewed, and approved by the authors. Each author has made a significant contribution to the creation and preparation of this manuscript. The author declares that there is no conflict of interest related to this study.
Databáze:	MEDLINE
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