Neurological manifestations in SARS-CoV-2 infection: A single-center cross-sectional study in Malaysia.

Autor: Tan HJ; Department of Medicine, Faculty of Medicine The National University of Malaysia Kuala Lumpur Malaysia., Goh CH; Department of Medicine, Faculty of Medicine The National University of Malaysia Kuala Lumpur Malaysia., Khoo CS; Department of Medicine, Faculty of Medicine The National University of Malaysia Kuala Lumpur Malaysia., Ng CF; Department of Medicine, Faculty of Medicine The National University of Malaysia Kuala Lumpur Malaysia., Tan JK; Department of Medicine, Faculty of Medicine The National University of Malaysia Kuala Lumpur Malaysia., Wan Zaidi WA; Department of Medicine, Faculty of Medicine The National University of Malaysia Kuala Lumpur Malaysia., Law ZK; Department of Medicine, Faculty of Medicine The National University of Malaysia Kuala Lumpur Malaysia., Zulkifli MD; Department of Medicine, Faculty of Medicine The National University of Malaysia Kuala Lumpur Malaysia., Md Rani SA; Department of Medicine, Faculty of Medicine The National University of Malaysia Kuala Lumpur Malaysia., Wan Yahya WNN; Department of Medicine, Faculty of Medicine The National University of Malaysia Kuala Lumpur Malaysia., Remli R; Department of Medicine, Faculty of Medicine The National University of Malaysia Kuala Lumpur Malaysia., Mohamed Ibrahim N; Department of Medicine, Faculty of Medicine The National University of Malaysia Kuala Lumpur Malaysia., Hod R; Department of Community Health, Faculty of Medicine The National University of Malaysia Kuala Lumpur Malaysia., Mohamed Mukari SA; Department of Radiology, Faculty of Medicine The National University of Malaysia Kuala Lumpur Malaysia., Mohd Mustapha AM; Department of Radiology, Faculty of Medicine The National University of Malaysia Kuala Lumpur Malaysia., Kori N; Department of Medicine, Faculty of Medicine The National University of Malaysia Kuala Lumpur Malaysia., Periyasamy P; Department of Medicine, Faculty of Medicine The National University of Malaysia Kuala Lumpur Malaysia.
Jazyk: angličtina
Zdroj: Neurology and clinical neuroscience [Neurol Clin Neurosci] 2023 Jan; Vol. 11 (1), pp. 17-26. Date of Electronic Publication: 2022 Nov 14.
DOI: 10.1111/ncn3.12677
Abstrakt: Background: Neurological involvement associated with SARS-CoV-2 infection has been reported from different regions of the world. However, data from South East Asia are scarce. We described the neurological manifestations and their associated factors among the hospitalized COVID-19 patients from an academic tertiary hospital in Malaysia.
Methods: A cross-sectional observational study of hospitalized COVID-19 patients was conducted. The neurological manifestations were divided into the self-reported central nervous system (CNS) symptoms, stroke associated symptoms, symptoms of encephalitis or encephalopathy and specific neurological complications. Multiple logistic regression was performed using demographic and clinical variables to determine the factors associated with outcome.
Results: Of 156 hospitalized COVID-19 patients with mean age of 55.88 ± 6.11 (SD) years, 23.7% developed neurological complications, which included stroke, encephalitis and encephalopathy. Patients with neurological complications were more likely to have diabetes mellitus ( p  = 0.033), symptoms of stroke [limb weakness ( p  < 0.001), slurred speech ( p  < 0.001)]; and encephalitis or encephalopathy [confusion ( p  < 0.001), forgetfulness ( p  = 0.006) and seizure ( p  = 0.019)]. Unvaccinated patients had a 4.25-fold increased risk of having neurological complications (adjusted OR = 4.25; 95% CI: 1.02, 17.71, p  = 0.047). Anosmia and dysgeusia were less associated with neurological complications (adjusted OR = 0.22; 95% CI: 0.05, 0.96, p  = 0.044). The odds of neurological complications were increased by 18% in patients with leukocytosis (adjusted OR = 1.18, 95% CI: 1.003, p  = 0.0460).
Conclusions: Stroke, encephalitis and encephalopathy were the common neurological complications from our study. Diabetes mellitus, presence of symptoms of stroke, symptoms of encephalitis or encephalopathy, leukocytosis, and being unvaccinated against COVID-19 were the associated risk factors of developing neurological complications.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest for this paper.
(© 2022 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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