Upper Airway Mucociliary Clearance is Impaired in Dyspneic COVID-19 Patients.

Autor: Pezato R; Av. Prof. Lineu Prestes, 2565 - Butantã, São Paulo, SP 05508-000 Brazil Departament of Ophathalmology and Otorhinolaryngology, University of Sao Paulo.; Vancouver, BC Canada Centre of Heart Lung Innovation, University of British Columbia.; São Paulo, Brazil Department of Otorhinolaryngology and Head and Neck Surgery, Universidade Federal de São Paulo., David AG; Vancouver, BC Canada Centre of Heart Lung Innovation, University of British Columbia.; São Paulo, Brazil Department of Otorhinolaryngology and Head and Neck Surgery, Universidade Federal de São Paulo., Boggi AC; São Paulo, Brazil Department of Otorhinolaryngology and Head and Neck Surgery, Universidade Federal de São Paulo.; Escola Superior de Bombeiros - Polícia Militar de São Paulo, Rod. Pref. Luiz Salomão Chamma, 3300 - Parque Industrial, Franco da Rocha, SP 07857-050 Brazil., Melo B; Av. Brasil, 4365 - Manguinhos, Rio de Janeiro, RJ 21040-900 Brazil Fundação Oswaldo Cruz., Rosalino CMV; Av. Brasil, 4365 - Manguinhos, Rio de Janeiro, RJ 21040-900 Brazil Fundação Oswaldo Cruz., Rodriguez AP; Vancouver, BC Canada Centre of Heart Lung Innovation, University of British Columbia., Thamboo A; Vancouver, BC Canada Centre of Heart Lung Innovation, University of British Columbia., Voegels RL; Av. Prof. Lineu Prestes, 2565 - Butantã, São Paulo, SP 05508-000 Brazil Departament of Ophathalmology and Otorhinolaryngology, University of Sao Paulo.
Jazyk: angličtina
Zdroj: Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India [Indian J Otolaryngol Head Neck Surg] 2023 Jun; Vol. 75 (2), pp. 772-776. Date of Electronic Publication: 2023 Jan 19.
DOI: 10.1007/s12070-022-03426-1
Abstrakt: Covid-19 is transmitted mainly by respiratory droplets and as the upper airway mucosa is the first innate immune barrier, it is crucial to understand the effects of SARS-CoV-2 on this system. In the current study, we aimed to evaluate the nasal mucociliary clearance in patients with SARS-CoV-2 infection and their symptom development. Observational cross-sectional study. The nasal mucociliary clearance (NMC) time was evaluated by the saccharin test and the results were compared between patients with SARS-CoV-2 infection (group 1) and controls (group 2, asymptomatic patients with a negative polymerase chain reaction test). We also compared the NMC time for each specific symptom suffered by participants in group 1 with the NMC time of the control group as well as with the patients in group 1 who were asymptomatic. There was a significant increase in NMC time in group 1 with dyspnea when compared to the control group ( p  = 0.032) and also when compared to patients who were infected were not dyspneic ( p  = 0.04). There were no differences in the clearance times when considering other symptoms. COVID-19 patients with dyspnea present with altered nasal mucociliary clearance.
Competing Interests: Conflict of interestThe authors declare that they have no conflict of interest.
(© Association of Otolaryngologists of India 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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