Diaminoanthraquinone Enhances Alkaloid Ionization in MALDI-MS.
| Autor: | Yamagaki T; Bioorganic Research Institute, Suntory Foundation for Life Sciences, 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan., Osawa T; Bioorganic Research Institute, Suntory Foundation for Life Sciences, 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Mass spectrometry (Tokyo, Japan) [Mass Spectrom (Tokyo)] 2022; Vol. 11 (1), pp. A0109. Date of Electronic Publication: 2022 Dec 28. |
| DOI: | 10.5702/massspectrometry.A0109 |
| Abstrakt: | The alkaloids epinastine, 3-methylxanthine and camptothecin were analyzed by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). The ionization efficiencies of epinastine and 3-methylxanthine were improved upon the addition of 1,5-diaminoanthraquinone (DAAQ). DAAQ did not show ultraviolet absorbance peaks at wavelengths around 337 nm and 355 nm that are used in conventional MALDI-MS instruments. In addition, the DAAQ ion peak was very weak relative to those of the analytes due to the low absorbance efficiency. These properties of DAAQ are advantageous for the DAAQ-MALDI-MS analysis of alkaloids. (Copyright © 2022 Tohru Yamagaki and Tsukiho Osawa.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|