Diffuse pulmonary ossification: A case report unveiling clinical and histopathological challenges.

Autor:	Polit F; Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL, 33140, USA., Alloush F; Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL, 33140, USA., Espinosa C; Department of Internal Medicine, Mount Sinai Medical Center, Miami Beach, FL, 33140, USA., Bahmad HF; Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL, 33140, USA., Gill A; Department of Radiology, Mount Sinai Medical Center, Miami Beach, FL, 33140, USA., Mendez L; Department of Internal Medicine, Mount Sinai Medical Center, Miami Beach, FL, 33140, USA., Urdaneta G; Department of Internal Medicine, Mount Sinai Medical Center, Miami Beach, FL, 33140, USA., Poppiti R; Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL, 33140, USA.; Herbert Wertheim College of Medicine, Florida International University, Miami, FL, 33174, USA., Recine M; Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL, 33140, USA.; Herbert Wertheim College of Medicine, Florida International University, Miami, FL, 33174, USA., Garcia H; Department of Internal Medicine, Mount Sinai Medical Center, Miami Beach, FL, 33140, USA.
Jazyk:	angličtina
Zdroj:	Respiratory medicine case reports [Respir Med Case Rep] 2023 Jan 19; Vol. 42, pp. 101815. Date of Electronic Publication: 2023 Jan 19 (Print Publication: 2023).
DOI:	10.1016/j.rmcr.2023.101815
Abstrakt:	Diffuse pulmonary ossification (DPO) is a rare pulmonary condition characterized by the diffuse formation of mature bone in the lungs. Pulmonary ossification, in general, can be subdivided into diffuse pulmonary ossification (DPO) and nodular pulmonary ossification (NPO). DPO occurs most commonly in the settings of chronic pulmonary conditions; however, idiopathic cases have been reported. We present a case of DPO in a 36-year-old man with progressive exertional dyspnea, productive cough, and occasional hemoptysis. Imaging studies showed innumerable pulmonary nodules scattered throughout both lungs. Initially, the diagnoses of pulmonary alveolar microlithiasis (PAM) or, less likely miliary tuberculosis (TB) were considered. However, Quantiferon TB test was negative and genetic testing was negative for SLC34A2 , lowering the probability of PAM. The patient underwent a segmentectomy. Microscopic examination showed ramifying spicules of mature woven bone and fatty marrow consistent with DPO. There were no significant underlying pathologic findings, such as interstitial fibrosis, granulomas, organizing pneumonia, or significant inflammation in the background lung parenchyma. In conclusion, clinicians and radiologists need to be aware of DPO in the differential diagnosis of miliary tuberculosis and pulmonary alveolar microlithiasis. The absence of an underlying chronic pulmonary condition does not exclude the possibility of DPO. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors.)
Databáze:	MEDLINE
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